Pauline Berthome1, Romain Tixier2, Jean Briand3, Olivier Geoffroy4, Dominique Babuty5, Jacques Mansourati6, Laurence Jesel7, Jean-Marc Dupuis8, Paul Bru9, Florence Kyndt10, Béatrice Guyomarch10, Aurélie Thollet10, Nathalie Behar3, Philippe Mabo3, Frédéric Sacher2, Vincent Probst10, Jean-Baptiste Gourraud11. 1. l'Institut du Thorax, CHU Nantes, Nantes, France. 2. Service de Cardiologie, Institut Lyric, CHU de Bordeaux, Bordeaux, France. 3. Service de Cardiologie, CHU de Rennes, Rennes, France. 4. Service de Cardiologie, CHU La Réunion, Saint-Denis de la Réunion, France. 5. Service de Cardiologie, CHU Tours, Tours, France. 6. Service de Cardiologie, CHU Brest, Brest, France. 7. Service de Cardiologie, CHRU Strasbourg, Strasbourg, France. 8. Service de Cardiologie, CHU Angers, Angers, France. 9. Service de Cardiologie, CH La Rochelle, La Rochelle, France. 10. l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France. 11. l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France. Electronic address: jeanbaptiste.gourraud@chu-nantes.fr.
Abstract
BACKGROUND: Studies in Brugada syndrome (BrS) have mainly consisted of men. OBJECTIVE: The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. METHODS: Consecutive BrS patients were enrolled from 1993 and followed prospectively. RESULTS: Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6-5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7-61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15-312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4-34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8-228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2-19.5; P = .03). CONCLUSION: Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.
BACKGROUND: Studies in Brugada syndrome (BrS) have mainly consisted of men. OBJECTIVE: The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. METHODS: Consecutive BrS patients were enrolled from 1993 and followed prospectively. RESULTS: Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6-5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7-61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15-312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4-34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8-228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2-19.5; P = .03). CONCLUSION:Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.
Authors: Estefanía Martínez-Barrios; Elena Arbelo; Sergi Cesar; José Cruzalegui; Victoria Fiol; Nuria Díez-Escuté; Clara Hernández; Ramon Brugada; Josep Brugada; Oscar Campuzano; Georgia Sarquella-Brugada Journal: Front Cardiovasc Med Date: 2022-04-11