Literature DB >> 30193106

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.

Haiyang Yu1, Don W Cleveland2.   

Abstract

Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30193106     DOI： 10.1016/j.cell.2018.08.035

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  3 in total

1.  Kinase Inhibitors for Treatment of Cancer and Inflammation.

Authors:  Robert B Kargbo
Journal:  ACS Med Chem Lett       Date:  2018-10-25       Impact factor: 4.345

Review 2.  Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis.

Authors:  Dylan V Neel; Himanish Basu; Georgia Gunner; Isaac M Chiu
Journal:  Immunol Rev       Date:  2022-05-07       Impact factor: 10.983

Review 3.  Targeting TANK-binding kinase 1 (TBK1) in cancer.

Authors:  Or-Yam Revach; Shuming Liu; Russell W Jenkins
Journal:  Expert Opin Ther Targets       Date:  2020-10-05       Impact factor: 6.902
  3 in total

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