Jun Sik Yoon1, Gyeonghwa Kim2, Yu Rim Lee1, Soo Young Park1, Won Young Tak1, Young-Oh Kweon1, Jung Gil Park3, Hye Won Lee4, Young Seok Han5, Heon Tak Ha5, Jae Min Chun5, Se Young Jang1, Keun Hur2. 1. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. 2. Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. 3. Departement of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea. 4. Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea. 5. Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Abstract
AIM: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). MATERIALS & METHODS: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. RESULTS: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. CONCLUSION: Elevated miR-21 expression might represent a biomarker for HCC prognosis.
AIM: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). MATERIALS & METHODS: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCCpatients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. RESULTS:MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage. CONCLUSION: Elevated miR-21 expression might represent a biomarker for HCC prognosis.