Hong Peng1, Yuan Yang1, Yue Zhao1, Hua Xiao1. 1. Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Abstract
BACKGROUND: To more precisely evaluate the effect of statins on patients with atrial fibrillation (AF) after catheter ablation, we performed a meta-analysis of published studies. METHODS: We searched PubMed, EMBASE, and Cochrane Library for all relevant published articles from the date of inception to April 2017. Odds ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled using a random-effects model. Statistical heterogeneity was evaluated using the I2 statistic. RESULTS: Nine studies with a total of 1,607 patients were included in the analysis. Overall, statins did not reduce the recurrence rate of AF after catheter ablation (OR 0.81, 95% CI 0.59-1.10, P = 0.18). However, in the subgroup analysis, the randomized control trial (RCT) group significantly reduced the recurrence of AF (OR 0.47, 95% CI 0.30-0.75, P = 0.001). Conversely, the retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI 0.78-1.36, P = 0.82). CONCLUSIONS: Statin use was associated with a significantly lower AF recurrence rate in RCTs but not in the whole analysis and the observational studies.
BACKGROUND: To more precisely evaluate the effect of statins on patients with atrial fibrillation (AF) after catheter ablation, we performed a meta-analysis of published studies. METHODS: We searched PubMed, EMBASE, and Cochrane Library for all relevant published articles from the date of inception to April 2017. Odds ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled using a random-effects model. Statistical heterogeneity was evaluated using the I2 statistic. RESULTS: Nine studies with a total of 1,607 patients were included in the analysis. Overall, statins did not reduce the recurrence rate of AF after catheter ablation (OR 0.81, 95% CI 0.59-1.10, P = 0.18). However, in the subgroup analysis, the randomized control trial (RCT) group significantly reduced the recurrence of AF (OR 0.47, 95% CI 0.30-0.75, P = 0.001). Conversely, the retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI 0.78-1.36, P = 0.82). CONCLUSIONS: Statin use was associated with a significantly lower AF recurrence rate in RCTs but not in the whole analysis and the observational studies.
Authors: Katarina Andelova; Barbara Szeiffova Bacova; Matus Sykora; Peter Hlivak; Miroslav Barancik; Narcis Tribulova Journal: Int J Mol Sci Date: 2022-01-26 Impact factor: 5.923
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