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Literature DB >> 3019111

Feline polymorphonuclear leukocytes respond chemotactically to leukotriene B4 and activated serum but not to F-Met-Leu-Phe.

G D Gray, G M Ohlmann, D R Morton, R G Schaub.

Abstract

The chemotactic response of feline polymorphonuclear leukocytes (PMNs) to three types of chemoattractants was studied. Feline PMNs responded to leukotriene B4 as well as to agarose-activated autologous and homologous serum. However, no response was obtained to N-formylmethionylleucylphenylalanine (FMLP), and four similar peptides that activate the FMLP receptor (N-formylnorleucylleucylphenylalanine, N-formylmethionylphenylalanine, methionylleucylphenylalanine, and pepstatin). Thus, feline PMNs are similar to equine, porcine, bovine and canine PMNs which also do not respond chemotactically to these peptides.

Entities: Chemical Species

Mesh：

Substances：

Year: 1986 PMID： 3019111 DOI： 10.1007/bf01965004

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

24 in total

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Authors: P M Henson
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

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Authors: S Aswanikumar; B Corcoran; E Schiffmann; A R Day; R J Freer; H J Showell; E L Becker
Journal: Biochem Biophys Res Commun Date: 1977-01-24 Impact factor: 3.575

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Authors: R J Freer; A R Day; J A Radding; E Schiffmann; S Aswanikumar; H J Showell; E L Becker
Journal: Biochemistry Date: 1980-05-27 Impact factor: 3.162

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Authors: G J Stewart; W G Ritchie; P R Lynch
Journal: Am J Pathol Date: 1974-03 Impact factor: 4.307

5. Aggregation, chemotaxis, and chemiluminescence of canine granulocytes. Studies utilizing improved cell preparation techniques.

Authors: H Redl; P J Flynn; H Lamche; A Schiesser; G Schlag; D E Hammerschmidt
Journal: Inflammation Date: 1983-03 Impact factor: 4.092

6. N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis.

Authors: R Snyderman; M C Pike
Journal: Science Date: 1980-07-25 Impact factor: 47.728

7. Receptor-directed inhibition of chemotactic factor-induced neutrophil hyperactivity by pyrazolon derivatives. Definition of a chemotactic peptide antagonist.

Authors: C Dahinden; J Fehr
Journal: J Clin Invest Date: 1980-11 Impact factor: 14.808

8. Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor.

Authors: R D Nelson; S K Ackerman; V D Fiegel; M P Bauman; S D Douglas
Journal: Infect Immun Date: 1979-12 Impact factor: 3.441

9. The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.

Authors: H J Showell; R J Freer; S H Zigmond; E Schiffmann; S Aswanikumar; B Corcoran; E L Becker
Journal: J Exp Med Date: 1976-05-01 Impact factor: 14.307

Feline polymorphonuclear leukocytes respond chemotactically to leukotriene B4 and activated serum but not to F-Met-Leu-Phe.

1. The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

2. Demonstration of a receptor on rabbit neutrophils for chemotactic peptides.

3. Further studies on the structural requirements for synthetic peptide chemoattractants.

4. Venous endothelial damage produced by massive sticking and emigration of leukocytes.

5. Aggregation, chemotaxis, and chemiluminescence of canine granulocytes. Studies utilizing improved cell preparation techniques.

6. N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis.

7. Receptor-directed inhibition of chemotactic factor-induced neutrophil hyperactivity by pyrazolon derivatives. Definition of a chemotactic peptide antagonist.

8. Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor.

9. The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.

10. Selective neutrophil desensitization to chemotactic factors.

Review 1. Rous-Whipple award lecture. The formylpeptide receptor of the neutrophil. A search and conserve operation.

2. Migration of dog polymorphonuclear neutrophilic leukocytes to formylated peptides.

3. In vitro effects of leukotriene B4 (LTB4) on canine PMN effector function(s).

4. Chemotactic properties and absence of the formyl peptide receptor in ferret (Mustela putorius furo) neutrophils.