Qiujin Shen1,1, Xin-Rong Yang2,2, Yexiong Tan3,3, Haiyan You1,1, Yang Xu2,2, Wei Chu1,1, Tianxiang Ge1,1, Jian Zhou2,2, Shuang-Jian Qiu2,2, Ying-Hong Shi2,2, Zhigang Zhang1,1, Jianren Gu1,1, Hongyang Wang3,3, Jia Fan2,2, Wenxin Qin1,1. 1. State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No.25/Ln 2200 XieTu Road, Shanghai 200032, China. 2. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis & Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China. 3. Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Abstract
AIM: To evaluate prognostic significance of DKK1 for hepatocelluar carcinoma. MATERIALS & METHODS: We enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model. RESULTS: High levels of preoperative serum DKK1 were associated with poor overall survival and higher recurrence rate and DKK1 was an independent prognostic predictor. Moreover, DKK1 maintained ability to predict recurrence for patients with low recurrence risk. Double positives of DKK1 and AFP indicated the worst overall survival and the highest recurrence rate compared with either used alone. Patients with preoperatively and 1-day postoperatively positive DKK1 had higher recurrence rates than those whose values were both negative. Similar results were found in the validation cohort. CONCLUSION: Serum DKK1 could predict prognosis of hepatocelluar carcinoma after hepatectomy.
AIM: To evaluate prognostic significance of DKK1 for hepatocelluar carcinoma. MATERIALS & METHODS: We enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model. RESULTS: High levels of preoperative serum DKK1 were associated with poor overall survival and higher recurrence rate and DKK1 was an independent prognostic predictor. Moreover, DKK1 maintained ability to predict recurrence for patients with low recurrence risk. Double positives of DKK1 and AFP indicated the worst overall survival and the highest recurrence rate compared with either used alone. Patients with preoperatively and 1-day postoperatively positive DKK1 had higher recurrence rates than those whose values were both negative. Similar results were found in the validation cohort. CONCLUSION: Serum DKK1 could predict prognosis of hepatocelluar carcinoma after hepatectomy.
Authors: Yujin Hoshida; Augusto Villanueva; Masahiro Kobayashi; Judit Peix; Derek Y Chiang; Amy Camargo; Supriya Gupta; Jamie Moore; Matthew J Wrobel; Jim Lerner; Michael Reich; Jennifer A Chan; Jonathan N Glickman; Kenji Ikeda; Masaji Hashimoto; Goro Watanabe; Maria G Daidone; Sasan Roayaie; Myron Schwartz; Swan Thung; Helga B Salvesen; Stacey Gabriel; Vincenzo Mazzaferro; Jordi Bruix; Scott L Friedman; Hiromitsu Kumada; Josep M Llovet; Todd R Golub Journal: N Engl J Med Date: 2008-10-15 Impact factor: 91.245