Literature DB >> 30190833

Pharmacist's role in optimizing therapy of the newer agents for the treatment of metastatic melanoma.

Gabriel Gazzé.   

Abstract

Metastatic melanoma is a disease with a historically dismal survival of 6-9 months with treatment. It is considered an incurable disease and resistant to conventional chemotherapy. We have learned much about the role of newer targets in the development of melanoma which has helped us in developing targeted therapy and improving immunotherapy for the treatment of melanoma. These new therapies have a different adverse event profile from conventional chemotherapy. We will define these and their management from the perspective of the oncology pharmacist. We will also discuss the role that the oncology pharmacist can play in optimizing therapy and side effect management in the multidisciplinary team treating patients that have unresectable or metastatic melanoma.

Entities:  

Keywords:  BRAF inhibitors; dabrafenib; immunotherapy; ipilimumab; melanoma; oncology pharmacist; trametinib; vemurafenib

Year:  2015        PMID: 30190833      PMCID: PMC6094589          DOI: 10.2217/mmt.14.33

Source DB:  PubMed          Journal:  Melanoma Manag        ISSN: 2045-0885


  21 in total

Review 1.  From genes to drugs: targeted strategies for melanoma.

Authors:  Keith T Flaherty; F Stephen Hodi; David E Fisher
Journal:  Nat Rev Cancer       Date:  2012-04-05       Impact factor: 60.716

Review 2.  Current management of melanoma.

Authors:  Erik M Dunki-Jacobs; Glenda G Callender; Kelly M McMasters
Journal:  Curr Probl Surg       Date:  2013-08       Impact factor: 1.909

Review 3.  New therapeutic options in systemic treatment of advanced cutaneous melanoma.

Authors:  Malgorzata Mackiewicz-Wysocka; Jakub Zolnierek; Piotr J Wysocki
Journal:  Expert Opin Investig Drugs       Date:  2012-12-08       Impact factor: 6.206

Review 4.  New therapies in the treatment of melanoma.

Authors:  Diwakar Davar; John Munn Kirkwood
Journal:  Expert Opin Investig Drugs       Date:  2012-08-09       Impact factor: 6.206

5.  Improved survival with ipilimumab in patients with metastatic melanoma.

Authors:  F Stephen Hodi; Steven J O'Day; David F McDermott; Robert W Weber; Jeffrey A Sosman; John B Haanen; Rene Gonzalez; Caroline Robert; Dirk Schadendorf; Jessica C Hassel; Wallace Akerley; Alfons J M van den Eertwegh; Jose Lutzky; Paul Lorigan; Julia M Vaubel; Gerald P Linette; David Hogg; Christian H Ottensmeier; Celeste Lebbé; Christian Peschel; Ian Quirt; Joseph I Clark; Jedd D Wolchok; Jeffrey S Weber; Jason Tian; Michael J Yellin; Geoffrey M Nichol; Axel Hoos; Walter J Urba
Journal:  N Engl J Med       Date:  2010-06-05       Impact factor: 91.245

Review 6.  Melanoma: new insights and new therapies.

Authors:  Vasiliki A Nikolaou; Alexander J Stratigos; Keith T Flaherty; Hensin Tsao
Journal:  J Invest Dermatol       Date:  2012-01-05       Impact factor: 8.551

Review 7.  Management of immune-related adverse events and kinetics of response with ipilimumab.

Authors:  Jeffrey S Weber; Katharina C Kähler; Axel Hauschild
Journal:  J Clin Oncol       Date:  2012-05-21       Impact factor: 44.544

Review 8.  Ipilimumab in the treatment of melanoma.

Authors:  Van A Trinh; Wen-Jen Hwu
Journal:  Expert Opin Biol Ther       Date:  2012-04-14       Impact factor: 4.388

Review 9.  Vemurafenib for the treatment of melanoma.

Authors:  Emmet John Jordan; Catherine M Kelly
Journal:  Expert Opin Pharmacother       Date:  2012-10-24       Impact factor: 3.889

Review 10.  Vemurafenib: targeted inhibition of mutated BRAF for treatment of advanced melanoma and its potential in other malignancies.

Authors:  Anant Sharma; Sachin R Shah; Henrik Illum; Jonathan Dowell
Journal:  Drugs       Date:  2012-12-03       Impact factor: 9.546

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  1 in total

Review 1.  Combination therapy for metastatic melanoma: a pharmacist's role, drug interactions & complementary alternative therapies.

Authors:  Gabriel Gazzé
Journal:  Melanoma Manag       Date:  2018-06-19
  1 in total

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