Lydia Poole1, Andrew Steptoe2. 1. Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, United Kingdom. Electronic address: lydia.poole@ucl.ac.uk. 2. Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, United Kingdom.
Abstract
OBJECTIVE: To assess the association between depressive symptoms and incident chronic illness burden in prospective longitudinal analyses. METHODS: We analysed data from 2472 participants (62.88 ± 8.49 years old; 50.8% female) from the English Longitudinal Study of Ageing (ELSA). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression (CES-D) scale at baseline in 2004, and participants were followed up for 10 years. Participants with prevalent illness at baseline (coronary heart disease [CHD], other cardiac illness, stroke, cancer, diabetes/high blood glucose, arthritis, lung disease, osteoporosis and Parkinson's disease) were excluded from models predicting illness burden (the sum of illnesses reported) over follow-up. Linear regression was used controlling for a wide range of covariates. RESULTS: The mean chronic illness burden was 0.57, with 43.1% experiencing at least one incident physical illness. Baseline continuous CES-D score was a significant predictor of incident chronic illness burden up to 10 years later (incident rate ratio = 1.05, 95% confidence intervals = 0.05-0.21, p = .003), independent of sociodemographic, behavioural, cognitive and clinical covariates. Sensitivity analyses excluding participants who developed a chronic illness within the 2 years following baseline corroborated the main results. CONCLUSION: Depressive symptoms were associated with greater incident chronic illness burden 10 years later. These findings have clinical implications for the treatment of depression in physically healthy older adults.
OBJECTIVE: To assess the association between depressive symptoms and incident chronic illness burden in prospective longitudinal analyses. METHODS: We analysed data from 2472 participants (62.88 ± 8.49 years old; 50.8% female) from the English Longitudinal Study of Ageing (ELSA). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression (CES-D) scale at baseline in 2004, and participants were followed up for 10 years. Participants with prevalent illness at baseline (coronary heart disease [CHD], other cardiac illness, stroke, cancer, diabetes/high blood glucose, arthritis, lung disease, osteoporosis and Parkinson's disease) were excluded from models predicting illness burden (the sum of illnesses reported) over follow-up. Linear regression was used controlling for a wide range of covariates. RESULTS: The mean chronic illness burden was 0.57, with 43.1% experiencing at least one incident physical illness. Baseline continuous CES-D score was a significant predictor of incident chronic illness burden up to 10 years later (incident rate ratio = 1.05, 95% confidence intervals = 0.05-0.21, p = .003), independent of sociodemographic, behavioural, cognitive and clinical covariates. Sensitivity analyses excluding participants who developed a chronic illness within the 2 years following baseline corroborated the main results. CONCLUSION:Depressive symptoms were associated with greater incident chronic illness burden 10 years later. These findings have clinical implications for the treatment of depression in physically healthy older adults.
Authors: Mareike Ernst; Elmar Brähler; Daniëlle Otten; Antonia M Werner; Ana N Tibubos; Iris Reiner; Felix Wicke; Jörg Wiltink; Matthias Michal; Markus Nagler; Thomas Münzel; Philipp S Wild; Jochem König; Norbert Pfeiffer; Andreas Borta; Karl J Lackner; Manfred E Beutel Journal: Sci Rep Date: 2021-01-26 Impact factor: 4.379
Authors: Jorge Arias-de la Torre; Amy Ronaldson; Matthew Prina; Faith Matcham; Snehal M Pinto Pereira; Stephani L Hatch; David Armstrong; Andrew Pickles; Matthew Hotopf; Alex Dregan Journal: Lancet Healthy Longev Date: 2021-12