Théo A Meister1, Stefano F Rimoldi1, Rodrigo Soria1, Robert von Arx1, Franz H Messerli1, Claudio Sartori2, Urs Scherrer3, Emrush Rexhaj4. 1. Department of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland. 2. Department of Internal Medicine, University Hospital, Lausanne, Switzerland. 3. Department of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland; Faculty of Sciences, Department of Biology, University of Tarapacá, Arica, Chile. 4. Department of Cardiology, University Hospital and Department for Biomedical Research, University of Bern, Bern, Switzerland. Electronic address: emrush.rexhaj@insel.ch.
Abstract
BACKGROUND: Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown. OBJECTIVES: This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group. METHODS: Five years after the initial assessment, the study investigators reassessed vascular function and performed 24-h ambulatory blood pressure (BP) monitoring (ABPM) in 54 young, apparently healthy participants conceived through ART and 43 age- and sex-matched controls. RESULTS: Premature vascular aging persisted in ART-conceived subjects, as evidenced by a roughly 25% impairment of flow-mediated dilation of the brachial artery (p < 0.001) and increased pulse-wave velocity and carotid intima-media thickness. Most importantly, ABPM values (systolic BP, 119.8 ± 9.1 mm Hg vs. 115.7 ± 7.0 mm Hg, p = 0.03; diastolic BP, 71.4 ± 6.1 mm Hg vs. 69.1 ± 4.2 mm Hg, p = 0.02 ART vs. control) and BP variability were markedly higher in ART-conceived subjects than in control subjects. Eight of the 52 ART participants, but only 1 of the 43 control participants (p = 0.041 ART vs. controls) fulfilled ABPM criteria of arterial hypertension (>130/80 mm Hg and/or >95th percentile). CONCLUSIONS: ART-induced premature vascular aging persists in apparently healthy adolescents and young adults without any other detectable classical cardiovascular risk factors and progresses to arterial hypertension. (Vascular Dysfunction in Offspring of Assisted Reproduction Technologies; NCT00837642.).
BACKGROUND: Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown. OBJECTIVES: This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group. METHODS: Five years after the initial assessment, the study investigators reassessed vascular function and performed 24-h ambulatory blood pressure (BP) monitoring (ABPM) in 54 young, apparently healthy participants conceived through ART and 43 age- and sex-matched controls. RESULTS: Premature vascular aging persisted in ART-conceived subjects, as evidenced by a roughly 25% impairment of flow-mediated dilation of the brachial artery (p < 0.001) and increased pulse-wave velocity and carotid intima-media thickness. Most importantly, ABPM values (systolic BP, 119.8 ± 9.1 mm Hg vs. 115.7 ± 7.0 mm Hg, p = 0.03; diastolic BP, 71.4 ± 6.1 mm Hg vs. 69.1 ± 4.2 mm Hg, p = 0.02 ART vs. control) and BP variability were markedly higher in ART-conceived subjects than in control subjects. Eight of the 52 ART participants, but only 1 of the 43 control participants (p = 0.041 ART vs. controls) fulfilled ABPM criteria of arterial hypertension (>130/80 mm Hg and/or >95th percentile). CONCLUSIONS: ART-induced premature vascular aging persists in apparently healthy adolescents and young adults without any other detectable classical cardiovascular risk factors and progresses to arterial hypertension. (Vascular Dysfunction in Offspring of Assisted Reproduction Technologies; NCT00837642.).
Authors: Wendy Y Zhang; Elif Seda Selamet Tierney; Angela C Chen; Albee Y Ling; Raquel R Fleischmann; Valerie L Baker Journal: J Pediatr Date: 2019-08-20 Impact factor: 4.406
Authors: Edwina H Yeung; Pauline Mendola; Rajeshwari Sundaram; Tzu-Chun Lin; Miranda M Broadney; Diane L Putnick; Sonia L Robinson; Kristen J Polinski; Jean Wactawski-Wende; Akhgar Ghassabian; Thomas G O'Connor; Robert E Gore-Langton; Judy E Stern; Erin Bell Journal: Fertil Steril Date: 2022-06-10 Impact factor: 7.490