Ying Shu1,2, Jing Liu1, Xiaoxi Zeng1,3, Hyokyoung G Hong4, Yi Li5, Hui Zhong1, Liang Ma1, Ping Fu1,3. 1. Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, China. 2. Division of Nephrology, The Third People's Hospital of Chengdu, Chengdu, China. 3. West China Biomedical Big Data Center, Sichuan University, Chengdu, China. 4. Michigan State University, East Lansing, Michigan, USA. 5. University of Michigan, Ann Arbor, Michigan, USA.
Abstract
BACKGROUND: Overhydration is common among peritoneal dialysis (PD) patients and can affect PD-related outcomes. This paper aims to systematically investigate whether bioimpedance-assessed overhydration is a predictor for mortality and technique failure in PD patients. METHODS: We conducted a systematic review and meta-analysis of cohort studies on overhydration and prognosis in PD patients, strictly complying with the Preferred Reporting Items for Systematical Reviews and Meta-analyses. RESULTS: Eight articles met the selection criteria and 5 studies were included in the meta-analysis. Meta-analyses-revealed overhydration, defined as a high ratio of extracellular water/total body water (ECW/TBW), was significantly associated with higher risk for all-cause mortality and technique failure. Other higher dichotomized overhydration indicators and continuous hydration variables all indicated overhydration as a significant risk factor for all-cause mortality. CONCLUSION: Overhydration, defined by a higher ratio of ECW/TBW, might be an independent predictor for all-cause mortality and technique failure among PD patients. However, more studies are needed to confirm this conclusion. Video Journal Club 'Cappuccino with Claudio Ronco' at https://www.karger.com/Journal/ArticleNews/223997?sponsor=52.
BACKGROUND: Overhydration is common among peritoneal dialysis (PD) patients and can affect PD-related outcomes. This paper aims to systematically investigate whether bioimpedance-assessed overhydration is a predictor for mortality and technique failure in PDpatients. METHODS: We conducted a systematic review and meta-analysis of cohort studies on overhydration and prognosis in PDpatients, strictly complying with the Preferred Reporting Items for Systematical Reviews and Meta-analyses. RESULTS: Eight articles met the selection criteria and 5 studies were included in the meta-analysis. Meta-analyses-revealed overhydration, defined as a high ratio of extracellular water/total body water (ECW/TBW), was significantly associated with higher risk for all-cause mortality and technique failure. Other higher dichotomized overhydration indicators and continuous hydration variables all indicated overhydration as a significant risk factor for all-cause mortality. CONCLUSION: Overhydration, defined by a higher ratio of ECW/TBW, might be an independent predictor for all-cause mortality and technique failure among PDpatients. However, more studies are needed to confirm this conclusion. Video Journal Club 'Cappuccino with Claudio Ronco' at https://www.karger.com/Journal/ArticleNews/223997?sponsor=52.
Authors: Frank M van der Sande; Esther R van de Wal-Visscher; Stefano Stuard; Ulrich Moissl; Jeroen P Kooman Journal: Blood Purif Date: 2019-12-18 Impact factor: 2.614
Authors: Christian Verger; Claudio Ronco; Wim Van Biesen; James Heaf; François Vrtovsnik; Manel Vera Rivera; Ilze Puide; Raymond Azar; Adelheid Gauly; Saynab Atiye; Tatiana De Los Ríos Journal: Front Med (Lausanne) Date: 2021-12-24
Authors: François Vrtovsnik; Christian Verger; Wim Van Biesen; Stanley Fan; Sug-Kyun Shin; Carmen Rodríguez; Isabel Garcia Méndez; Frank M van der Sande; Tatiana De Los Ríos; Katharina Ihle; Adelheid Gauly; Claudio Ronco; James Heaf Journal: Clin Kidney J Date: 2019-12-22