B Postigo-Alonso1, A Galvao-Carmona2, I Benítez3, C Conde-Gavilán4, A Jover4, S Molina4, M A Peña-Toledo4, E Agüera4. 1. Department of Psychology, Universidad Loyola Andalucía, Seville, Spain; Human Neuroscience Lab (HNL), Universidad Loyola Andalucía, Seville, Spain. Electronic address: bpostigo@uloyola.es. 2. Department of Psychology, Universidad Loyola Andalucía, Seville, Spain; Human Neuroscience Lab (HNL), Universidad Loyola Andalucía, Seville, Spain; Institute of Biomedical Sciences, Universidad Autónoma de Chile, Santiago, Chile. 3. Department of Psychology, Universidad Loyola Andalucía, Seville, Spain. 4. Dementia and Multiple Sclerosis Unit, Neurology Service, Reina Sofía University Hospital, Córdoba, Spain.
Abstract
BACKGROUND: Cognitive-motor interference (CMI) has been proposed as a valid marker of daily life impairment in Multiple Sclerosis (MS). The heterogeneity and scarce number of studies regarding CMI in MS has hampered the synthesis of the existing evidence. The present systematic review employed a mixed methods approach with the aim of identifying and describing variables under which CMI is particularly useful to assess patients with MS. RESULTS: MS patients showed significant CMI. The motor variables that were most sensitive in detecting significant CMI were velocity (m/s), cadence (steps/min), and double support (% gait cycle), which was also specific for MS. Among the cognitive tasks, Alternate Alphabet and Serial Subtracting 7 s were sensitive, whereas Verbal Fluency were both sensitive and specific to CMI in MS. CONCLUSIONS: CMI should be assessed in MS with a standardised dual task such as the Verbal Fluency task while walking, with measurements of the double support time and the effect on the cognitive task. The clinical usefulness of CMI in the assessment of patients with MS is discussed.
BACKGROUND: Cognitive-motor interference (CMI) has been proposed as a valid marker of daily life impairment in Multiple Sclerosis (MS). The heterogeneity and scarce number of studies regarding CMI in MS has hampered the synthesis of the existing evidence. The present systematic review employed a mixed methods approach with the aim of identifying and describing variables under which CMI is particularly useful to assess patients with MS. RESULTS: MS patients showed significant CMI. The motor variables that were most sensitive in detecting significant CMI were velocity (m/s), cadence (steps/min), and double support (% gait cycle), which was also specific for MS. Among the cognitive tasks, Alternate Alphabet and Serial Subtracting 7 s were sensitive, whereas Verbal Fluency were both sensitive and specific to CMI in MS. CONCLUSIONS: CMI should be assessed in MS with a standardised dual task such as the Verbal Fluency task while walking, with measurements of the double support time and the effect on the cognitive task. The clinical usefulness of CMI in the assessment of patients with MS is discussed.
Authors: Renee Veldkamp; Ilse Baert; Alon Kalron; Andrea Tacchino; Mieke D'hooge; Ellen Vanzeir; Fanny Van Geel; Joke Raats; Mieke Goetschalckx; Giampaolo Brichetto; Nov Shalmoni; Peter Hellinckx; Natasja De Weerdt; Dorien De Wilde; Peter Feys Journal: J Clin Med Date: 2019-12-10 Impact factor: 4.241