Hemen Moradi-Sardareh1, Hamid Reza Ghasemi Basir2, Zuhair Mohammad Hassan3, Maryam Davoudi1, Fardin Amidi4, Maliheh Paknejad5. 1. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Pathology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran. 3. Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran. 4. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 5. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: paknejadma@tums.ac.ir.
Abstract
AIM: The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice. MAIN METHODS: Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively. KEY FINDINGS: Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum. SIGNIFICANCE: The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.
AIM: The main purpose of the current study was to evaluate the toxicity of silver nanoparticles (Ag NPs) on adult Balb/C mice. MAIN METHODS: Twenty five Balb/C mice purchased and divided into four groups of five. Group one serves as control and injected by normal saline; group's two to four were injected by Ag NPs at 0.25, 0.50 and 1 mg/kg, respectively. KEY FINDINGS: Overall, current results indicate that all concentration of Ag NPs have potential for induction of toxicity in different tissues. Ag NPs at concentration >0.25 mg/kg result in pathological changes in liver, spleen, brain, heart, lungs, kidneys, and testicles tissues; as well as it lead to significant change in sperm quality and quantity, and blood brain barrier (BBB) permeability. Ag NPs at the lowest concentration (0.25 mg/kg) significantly changed the oxidative stress levels in serum and liver tissue but did not change the level of liver enzymes and renal markers in serum. SIGNIFICANCE: The current research results support clearly the toxic effects of Ag NPs at very low concentration and suggest that further in vivo investigation are required to be able to confirm the safety of nanoparticle derived application to use in life.
Authors: Wolfgang G Kreyling; Uwe Holzwarth; Stephanie Hirn; Carsten Schleh; Alexander Wenk; Martin Schäffler; Nadine Haberl; Neil Gibson Journal: Part Fibre Toxicol Date: 2020-06-05 Impact factor: 9.400
Authors: Irina V Kiseleva; Mohammad Al Farroukh; Ekaterina A Skomorokhova; Andrei R Rekstin; Ekaterina A Bazhenova; Daria N Magazenkova; Iurii A Orlov; Larisa G Rudenko; Massimo Broggini; Ludmila V Puchkova Journal: Vaccines (Basel) Date: 2020-11-13