Garrett T Prince1, Michael C Cameron1, Ramin Fathi2, Theodore Alkousakis1. 1. Department of Dermatology and Cutaneous Surgery, University of Colorado School of Medicine, Aurora, CO, USA. 2. Department of Dermatology, University of Texas Southwestern Medical Center, Aurora, CO, USA.
Abstract
BACKGROUND: 5-fluorouracil (5-FU) has proven to be an effective therapy in the treatment of a variety of dermatologic conditions. Approved by the United States Food and Drug Administration for the treatment of actinic keratoses and superficial basal cell carcinoma, topical 5-FU has also demonstrated efficacy in the treatment of a variety of other dermatologic diseases. METHODS: A search of the MEDLINE standard computer database, MEDLINE advanced database, and EMBASE database was conducted. RESULTS: Thirty-four articles met criteria for inclusion in this review. These articles represented 16 randomized controlled trials and 18 case series. Each article was reviewed and summarized. CONCLUSIONS: Topical 5-FU is used in a variety of dermatologic disease processes with a wide range of efficacy and levels of evidence. Based on extent and level of evidence, our disease-specific systematic review found that the evidence is strongest for topical 5-FU use in the treatment of actinic keratosis, squamous cell carcinoma, and basal cell carcinoma. This review serves as a comprehensive summary of topical 5-FU use in dermatology.
BACKGROUND:5-fluorouracil (5-FU) has proven to be an effective therapy in the treatment of a variety of dermatologic conditions. Approved by the United States Food and Drug Administration for the treatment of actinic keratoses and superficial basal cell carcinoma, topical 5-FU has also demonstrated efficacy in the treatment of a variety of other dermatologic diseases. METHODS: A search of the MEDLINE standard computer database, MEDLINE advanced database, and EMBASE database was conducted. RESULTS: Thirty-four articles met criteria for inclusion in this review. These articles represented 16 randomized controlled trials and 18 case series. Each article was reviewed and summarized. CONCLUSIONS: Topical 5-FU is used in a variety of dermatologic disease processes with a wide range of efficacy and levels of evidence. Based on extent and level of evidence, our disease-specific systematic review found that the evidence is strongest for topical 5-FU use in the treatment of actinic keratosis, squamous cell carcinoma, and basal cell carcinoma. This review serves as a comprehensive summary of topical 5-FU use in dermatology.
Authors: Ana M T D P V Cabral; Ana C G Fernandes; Neuza A M Joaquim; Francisco Veiga; Sara P C Sofio; Isabel Paiva; Miguel A Esteso; M Melia Rodrigo; Artur J M Valente; Ana C F Ribeiro Journal: Toxics Date: 2022-06-01
Authors: Abdul Shakur Khan; Kifayat Ullah Shah; Mohammed Al Mohaini; Abdulkhaliq J Alsalman; Maitham A Al Hawaj; Yousef N Alhashem; Shakira Ghazanfar; Kamran Ahmad Khan; Zahid Rasul Niazi; Arshad Farid Journal: Gels Date: 2022-02-18