Literature DB >> 30187829

Size-Dependent Cortical Compaction Induces Metabolic Adaptation in Mesenchymal Stem Cell Aggregates.

Brent M Bijonowski1, Susan I Daraiseh2, Xuegang Yuan1, Teng Ma1.   

Abstract

IMPACT STATEMENT: This study reveals that multicellular aggregation induces metabolic reprogramming via mechanical compaction in lieu of formation of a hypoxic core. Utilizing biomechanical knowledge gained from planar culture, we set forth a novel three-dimensional (3D) model of size-dependent cortical compaction and demonstrated its role in metabolic reconfiguration. Ultimately, this study establishes mechanical compaction and its spatial gradients as key regulatory factors and design parameters in the development of 3D human adipose-derived mesenchymal stem cell aggregates.

Entities:  

Keywords:  PI3K; adipose-derived stem cells; aggregation; aldolase A; metabolic reprogramming; oxygen tension

Mesh：

Substances：

Year:  2019        PMID： 30187829      PMCID： PMC6482905          DOI： 10.1089/ten.TEA.2018.0155

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  50 in total

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Review 4.  Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy?

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Journal:  Front Immunol       Date:  2019-05-08       Impact factor: 7.561

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6.  Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration.

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7.  NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro.

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9.  Alginate Core-Shell Capsules for 3D Cultivation of Adipose-Derived Mesenchymal Stem Cells.

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