Literature DB >> 3018731

Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets.

H Ishii, T M Connolly, T E Bross, P W Majerus.   

Abstract

Cleavage of polyphosphoinositides in vitro by phospholipase C results in formation of both cyclic and noncyclic inositol phosphates. We have now isolated the cyclic product of phosphatidylinositol 4,5-bisphosphate cleavage, inositol 1,2(cyclic)-4,5-triphosphate [cIns(1:2,4,5)P3], from thrombin-treated platelets. We found 0.2-0.4 nmol of cIns-(1:2,4,5)P3 per 10(9) platelets at 10 sec after thrombin; none was found in unstimulated platelets or in platelets 10 min after thrombin addition. We conclude that cIns(1:2,4,5)P3 is a major product of polyphosphoinositide metabolism in thrombin-stimulated platelets.

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Year:  1986        PMID： 3018731      PMCID： PMC386510          DOI： 10.1073/pnas.83.17.6397

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

Review 1.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

2.  Production of phosphoinositide-derived messengers.

Authors:  P W Majerus; E J Neufeld; D B Wilson
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

3.  18O labeling of adenine nucleotide alpha-phosphoryls in platelets. Contribution by phosphodiesterase-catalyzed hydrolysis of cAMP.

Authors:  T F Walseth; J E Gander; S J Eide; T P Krick; N D Goldberg
Journal:  J Biol Chem       Date:  1983-02-10       Impact factor: 5.157

4.  Phosphoinositide interconversion in thrombin-stimulated human platelets.

Authors:  D B Wilson; E J Neufeld; P W Majerus
Journal:  J Biol Chem       Date:  1985-01-25       Impact factor: 5.157

5.  Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.

Authors:  D B Wilson; T E Bross; W R Sherman; R A Berger; P W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

6.  Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

Authors:  T M Connolly; T E Bross; P W Majerus
Journal:  J Biol Chem       Date:  1985-07-05       Impact factor: 5.157

7.  Phosphatidylinositol 4,5-bisphosphate may represent the site of release of plasma membrane-bound calcium upon stimulation of human platelets.

Authors:  M J Broekman
Journal:  Biochem Biophys Res Commun       Date:  1984-04-16       Impact factor: 3.575

Review 8.  Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Authors:  M J Berridge; R F Irvine
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

9.  Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

Authors:  D B Wilson; T E Bross; S L Hofmann; P W Majerus
Journal:  J Biol Chem       Date:  1984-10-10       Impact factor: 5.157

10.  Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

Authors:  S E Rittenhouse; J P Sasson
Journal:  J Biol Chem       Date:  1985-07-25       Impact factor: 5.157
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  12 in total

1.  Metabolism and function of membrane lipids.

Authors:  E P Kennedy
Journal:  Klin Wochenschr       Date:  1987-03-02

2.  Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells.

Authors:  S Muallem; S J Pandol; T G Beeker
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

3.  Regulation of glycerol synthesis in response to osmotic changes in dunaliella.

Authors:  E Chitlaru; U Pick
Journal:  Plant Physiol       Date:  1991-05       Impact factor: 8.340

4.  Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes.

Authors:  T K Harden; P T Hawkins; L Stephens; J L Boyer; C P Downes
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857

5.  Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate.

Authors:  R J Auchus; S L Kaiser; P W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

6.  Isolation of 1-monomethylphosphoinositol 4,5-bisphosphate [a product of methanolysis of inositol 1,2-(cyclic)-4,5-trisphosphate] from Swiss mouse 3T3 cells.

Authors:  D L Lips; T E Bross; P W Majerus
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

7.  Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells.

Authors:  N S Wong; C J Barker; S B Shears; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

8.  Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations.

Authors:  I H Batty; A J Letcher; S R Nahorski
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

9.  Aberrant 3H labelling of ATP during in vivo labelling of Ehrlich mouse ascites tumour cells with [2-3H]inositol is significant in the study of isomers of InsP3 and InsP4.

Authors:  S Christensen; H Harbak; L O Simonsen
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

10.  Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets.

Authors:  J L Daniel; C A Dangelmaier; J B Smith
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857
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