Literature DB >> 3018632

Pyridazinyl-GABA derivatives as GABA and glycine antagonists in the spinal cord of the cat.

B D Gynther, D R Curtis.   

Abstract

Of two arylaminopyridazine derivatives of gamma-aminobutyric acid (GABA) tested as antagonists of the inhibitory actions of glycine and GABA in the spinal cord of pentobarbitone-anaesthetized cats, one - SR95531 - was sufficiently selective to be of use in microelectrophoretic investigations of GABA-mediated synaptic transmission.

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Year:  1986        PMID： 3018632     DOI： 10.1016/0304-3940(86)90144-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  Effects of GABA antagonists, SR 95531 and bicuculline, on GABAA receptor-regulated chloride flux in rat cortical synaptoneurosomes.

Authors:  S Yu; I K Ho
Journal:  Neurochem Res       Date:  1990-09       Impact factor: 3.996

2.  New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.

Authors:  Tommy Sander; Bente Frølund; Anne Techau Bruun; Ivaylo Ivanov; James Andrew McCammon; Thomas Balle
Journal:  Proteins       Date:  2011-03-01

3.  Evaluation of the effect of jobelyn(®) on chemoconvulsants-induced seizure in mice.

Authors:  Solomon Umukoro; Itivere Adrian Omogbiya; Anthony Taghogho Eduviere
Journal:  Basic Clin Neurosci       Date:  2013

4.  A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites.

Authors:  Rikke Bergmann; Kristine Kongsbak; Pernille Louise Sørensen; Tommy Sander; Thomas Balle
Journal:  PLoS One       Date:  2013-01-07       Impact factor: 3.240
  4 in total

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