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Literature DB >> 301860

Suppressive effect of cyclophosphamide on the T-cell system in chickens.

Abstract

Neonatal administration of 16 mg of cyclophosphamide in inbred chickens resulted in a transient, but profound, deficiency in the in vitro proliferative response of spleen cells. Functional T-cell deficiency was accompanied by a marked morphological degeneration in the thymus and thymus-dependent areas in the spleen.

Entities: Chemical Disease Species

Mesh：

Substances：
Cyclophosphamide

Year: 1977 PMID： 301860 PMCID： PMC421104 DOI： 10.1128/iai.17.1.227-230.1977

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

23 in total

1. PROLONGATION OF HOMOGRAFT SURVIVAL IN MICE WITH SINGLE DOSES OF CYCLOPHOSPHAMIDE.

Authors: M C BERENBAUM; I N BROWN
Journal: Nature Date: 1963-10-05 Impact factor: 49.962

2. Depressed T-cell reactivity and suppressor activity of lymoid cells from cyclophosphamide-treated mice.

Authors: J D Milton; C B Carpenter; I E Addison
Journal: Cell Immunol Date: 1976-06-15 Impact factor: 4.868

3. The relationship between the immunoglobulin class of B-cell precursors and the degree of synergism obtained from the presence of T cells.

Authors: H R Anderson; D W Dresser; H H Wortis
Journal: Clin Exp Immunol Date: 1974-03 Impact factor: 4.330

4. The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens.

Authors: S P Lerman; W P Weidanz
Journal: J Immunol Date: 1970-09 Impact factor: 5.422

5. Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chickens.

Authors: T J Linna; D Frommel; R A Good
Journal: Int Arch Allergy Appl Immunol Date: 1972

Suppressive effect of cyclophosphamide on the T-cell system in chickens.

1. PROLONGATION OF HOMOGRAFT SURVIVAL IN MICE WITH SINGLE DOSES OF CYCLOPHOSPHAMIDE.

2. Depressed T-cell reactivity and suppressor activity of lymoid cells from cyclophosphamide-treated mice.

3. The relationship between the immunoglobulin class of B-cell precursors and the degree of synergism obtained from the presence of T cells.

4. The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens.

5. Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chickens.

6. Functional and morphological observations on the effect of cyclophosphamide on the immune response of the chicken.

7. Vaccinal immunity to Marek's disease in bursectomised chickens.

8. Effect of in ovo treatment with cyclophosphamide on lymphoid system in chicken.

9. Defective in vitro spleen cell proliferative response to antigens in agammaglobulinemic chickens.

10. Ontogeny of bursal function in chicken. 3. Immunocompletent cell for humoral immunity.

1. Immunity to coccidiosis: T-lymphocyte- or B-lymphocyte-deficient animals.

2. Influence of the bursa of Fabricius on the pathogenesis of Marek's disease.