| Literature DB >> 30184727 |
Chaoyue Zhao1, Jiulong Zhang2, Haiyang Hu2, Mingxi Qiao2, Dawei Chen2, Xiuli Zhao3, Chunrong Yang4.
Abstract
Blood-brain barrier (BBB) was the major obstacle for efficient delivery of therapeutic agents to brain tissue. To overcome this barrier, a novel lactoferrin modified long circulation nanostructured lipid carriers (Lf-NLC) was designed and synthesized for the efficient delivery of neuroprotective agent nimodipine (NMD) to brain tissue. NMD loaded Lf-NLC was optimized to exhibit a small and uniform particle size distribution and high loading content. More interestingly, Lf-NLC showed the excellent neuroprotective effect due to the efficient intracellular delivery NMD, in PC12 based stroke cell model induced by sodium nitroprusside (SNP). Cellular uptake assay indicated that Lf-NLC could be internalized into cytoplasm via Lf-receptor mediated endocytosis pathway. In vivo biodistribution assay demonstrated Lf-NLC could efficiently deliver therapeutic agent to brain tissue, indicating its promising application in brain delivery.Entities:
Keywords: Brain target; Lactoferrin; Nanostructured lipid carries; Nimodipine; Systematic evaluation
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Year: 2018 PMID： 30184727 DOI： 10.1016/j.msec.2018.02.004
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328