Raffaele Addeo1, Liliana Montella2, Amerigo Mastella3, Bruno Vincenzi4, Salvatore Mazzone5, Filippo Ricciardiello6, Salvatore Del Prete2. 1. U.O.C. Oncologia, "S. Giovanni di Dio" Hospital, ASLNA2NORD Frattamaggiore, Frattamaggiore, Italylelloaddeo@alice.it. 2. U.O.C. Oncologia, "S. Giovanni di Dio" Hospital, ASLNA2NORD Frattamaggiore, Frattamaggiore, Italy. 3. U.O.C. ORL, "Santa Maria Delle Grazie "Hospital, Pozzuoli, ASLNA2NORD Frattamaggiore, Frattamaggiore, Italy. 4. Section of Oncology, Campus Biomedico University, Rome, Italy. 5. Dipartimento di Salute Mentale Fisica e Medicina Preventiva, SUN Napoli, Napoli, Italy. 6. U.O.C. ORL, AORN "Cardarelli", Napoli, Italy.
Abstract
OBJECTIVES: This study evaluates maintenance cetuximab administered every 2 weeks (q2w) after chemotherapy plus cetuximab as first-line treatment in a series of patients with head and neck squamous cell cancer and compares the results with those obtained in a historical control group of patients receiving weekly cetuximab. METHODS: After chemotherapy plus cetuximab as first-line treatment, in Group A, 36 patients enrolled from October 2016 to November 2017, received biweekly cetuximab, administered at 500 mg/m2. Group B was a control group of patients treated at our institution from August 2015 to September 2016 and received weekly infusion of cetuximab at 250 mg/m2. RESULTS: Confirmed overall response rates were, respectively, 19% for Group A and 17% for Group B according to intention-to-treat analysis. During the maintenance treatment, median progression-free survival (PFS) and median overall survival (OS) were similar for both groups (PFS, 4.8 and 4.4 months; OS, 9.0 and 7.9 months; in Groups A and B, respectively). The most common adverse events among treated subjects included fatigue, rash, and hypomagnesemia. CONCLUSION: Maintenance therapy with simplified biweekly cetuximab is a convenient, effective, and well-tolerated regimen in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.
OBJECTIVES: This study evaluates maintenance cetuximab administered every 2 weeks (q2w) after chemotherapy plus cetuximab as first-line treatment in a series of patients with head and neck squamous cell cancer and compares the results with those obtained in a historical control group of patients receiving weekly cetuximab. METHODS: After chemotherapy plus cetuximab as first-line treatment, in Group A, 36 patients enrolled from October 2016 to November 2017, received biweekly cetuximab, administered at 500 mg/m2. Group B was a control group of patients treated at our institution from August 2015 to September 2016 and received weekly infusion of cetuximab at 250 mg/m2. RESULTS: Confirmed overall response rates were, respectively, 19% for Group A and 17% for Group B according to intention-to-treat analysis. During the maintenance treatment, median progression-free survival (PFS) and median overall survival (OS) were similar for both groups (PFS, 4.8 and 4.4 months; OS, 9.0 and 7.9 months; in Groups A and B, respectively). The most common adverse events among treated subjects included fatigue, rash, and hypomagnesemia. CONCLUSION: Maintenance therapy with simplified biweekly cetuximab is a convenient, effective, and well-tolerated regimen in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.
Authors: Ambika Parmar; Michaelina Macluskey; Niall Mc Goldrick; David I Conway; Anne-Marie Glenny; Janet E Clarkson; Helen V Worthington; Kelvin Kw Chan Journal: Cochrane Database Syst Rev Date: 2021-12-20
Authors: Dina Oksen; Patricia Prince; Emmanuelle Boutmy; Elizabeth M Garry; Barbara Ellers-Lenz; Adina Estrin; Andreas Johne; Patrice Verpillat; Nicolle M Gatto Journal: Clin Transl Sci Date: 2022-06-11 Impact factor: 4.438