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Literature DB >> 30184481

A Mitochondrial-Derived Peptide Exercises the Nuclear Option.

Kailash C Mangalhara¹, Gerald S Shadel².

Abstract

The vast majority of mitochondrial proteins are encoded by nuclear genes, giving the nucleus ultimate control of mitochondrial biogenesis, dynamics, and function. However, in this issue Kim et al. (2018) demonstrate a reversal of fortune, whereby an mtDNA-encoded peptide, MOTS-c, is targeted to the nucleus to signal changes in gene expression.

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Year: 2018 PMID： 30184481 DOI： 10.1016/j.cmet.2018.08.017

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

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Cited

10 in total

Review 1. Mitonuclear genomics and aging.

Authors: Joseph C Reynolds; Conscience P Bwiza; Changhan Lee
Journal: Hum Genet Date: 2020-01-29 Impact factor: 4.132

2. Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria.

Authors: Daria Skuratovskaia; Alexandra Komar; Maria Vulf; Larisa Litvinova
Journal: PeerJ Date: 2020-08-25 Impact factor: 2.984

3. Evolution of Mitochondrially Derived Peptides Humanin and MOTSc, and Changes in Insulin Sensitivity during Early Gestation in Women with and without Gestational Diabetes.

Authors: David Ruiz; Miguel Santibañez; Bernardo Alio Lavín; Ana Berja; Coral Montalban; Luis Alberto Vazquez
Journal: J Clin Med Date: 2022-05-26 Impact factor: 4.964

Review 4. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Authors: Bérénice A Benayoun; Changhan Lee
Journal: Bioessays Date: 2019-08-05 Impact factor: 4.345

Review 5. Mitochondria: multifaceted regulators of aging.

Authors: Jyung Mean Son; Changhan Lee
Journal: BMB Rep Date: 2019-01 Impact factor: 4.778

6. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

Authors: Joseph C Reynolds; Rochelle W Lai; Jonathan S T Woodhead; James H Joly; Cameron J Mitchell; David Cameron-Smith; Ryan Lu; Pinchas Cohen; Nicholas A Graham; Bérénice A Benayoun; Troy L Merry; Changhan Lee
Journal: Nat Commun Date: 2021-01-20 Impact factor: 14.919

A Mitochondrial-Derived Peptide Exercises the Nuclear Option.

Review 1. Mitonuclear genomics and aging.

2. Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria.

3. Evolution of Mitochondrially Derived Peptides Humanin and MOTSc, and Changes in Insulin Sensitivity during Early Gestation in Women with and without Gestational Diabetes.

Review 4. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Review 5. Mitochondria: multifaceted regulators of aging.

6. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

Review 7. Novel Insights Into the Role of Mitochondria-Derived Peptides in Myocardial Infarction.

Review 8. Mitochondrial-Derived Peptides in Diabetes and Its Complications.

Review 9. Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management.

Review 10. PGC-1α protects from myocardial ischaemia-reperfusion injury by regulating mitonuclear communication.