Background: Inadequate complementary feeding is common in low- and middle-income countries, contributing to growth deficits. Complementary food supplements (CFSs) aim to fill dietary gaps, but few CFS studies have measured nutrient intake. In a community-based, randomized CFS trial in Bangladesh, we previously reported poor dietary diversity in 6-18-mo-old participants. Objective: We investigated, in a secondary analysis in the same trial, micronutrient intake adequacy in supplemented compared with control-arm children. Methods: At age 6 mo, children were assigned to 1 y of child-feeding counseling for mothers (control) or counseling plus 1 of 4 CFS formulations. Mothers were administered quantitative past 24-h diet questionnaires for their children at ages 6, 9, 12, 15, and 18 mo. Nutrient intakes were estimated with local recipes and food composition tables assuming average age-specific breastmilk intake. Adequacy was evaluated relative to estimated average requirements or adequate intakes. Multivariate analysis of variance and generalized estimating equation (GEE) regression models estimated the effect of each CFS on nutrient adequacy. GEE models tested dietary predictors of nutrient adequacy in the control arm. Results: A total of 25,964 dietary modules across 5 interviews were completed. Nutrient adequacy from home foods combined with assumed breastmilk intake was low. Only 5 of 16 micronutrients were adequately consumed by >60% of children at 18 mo of age. Daily CFSs did not affect energy-adjusted micronutrient intake from home foods at any follow-up age (P > 0.05). CFSs increased the mean adequacy ratio for all micronutrients (P < 0.001 at all ages), to ≥1 for 14 of 16 micronutrients at 18 mo. Dietary diversity predicted adequate iron, zinc and calcium intake at 15 mo in unsupplemented controls. Conclusions: Home foods did not meet the estimated micronutrient needs of 9-18-mo-old children in rural Bangladesh. Daily supplementation with fortified complementary foods filled many micronutrient intake gaps and did not displace home foods. Previously, CFSs were shown to also improve linear growth and reduce stunting in this cohort. Findings support the need for CFSs in similar settings to promote nutritional well being and growth. This trial was registered at clinicaltrials.gov as NCT01562379.
RCT Entities:
Background: Inadequate complementary feeding is common in low- and middle-income countries, contributing to growth deficits. Complementary food supplements (CFSs) aim to fill dietary gaps, but few CFS studies have measured nutrient intake. In a community-based, randomized CFS trial in Bangladesh, we previously reported poor dietary diversity in 6-18-mo-old participants. Objective: We investigated, in a secondary analysis in the same trial, micronutrient intake adequacy in supplemented compared with control-arm children. Methods: At age 6 mo, children were assigned to 1 y of child-feeding counseling for mothers (control) or counseling plus 1 of 4 CFS formulations. Mothers were administered quantitative past 24-h diet questionnaires for their children at ages 6, 9, 12, 15, and 18 mo. Nutrient intakes were estimated with local recipes and food composition tables assuming average age-specific breastmilk intake. Adequacy was evaluated relative to estimated average requirements or adequate intakes. Multivariate analysis of variance and generalized estimating equation (GEE) regression models estimated the effect of each CFS on nutrient adequacy. GEE models tested dietary predictors of nutrient adequacy in the control arm. Results: A total of 25,964 dietary modules across 5 interviews were completed. Nutrient adequacy from home foods combined with assumed breastmilk intake was low. Only 5 of 16 micronutrients were adequately consumed by >60% of children at 18 mo of age. Daily CFSs did not affect energy-adjusted micronutrient intake from home foods at any follow-up age (P > 0.05). CFSs increased the mean adequacy ratio for all micronutrients (P < 0.001 at all ages), to ≥1 for 14 of 16 micronutrients at 18 mo. Dietary diversity predicted adequate iron, zinc and calcium intake at 15 mo in unsupplemented controls. Conclusions: Home foods did not meet the estimated micronutrient needs of 9-18-mo-old children in rural Bangladesh. Daily supplementation with fortified complementary foods filled many micronutrient intake gaps and did not displace home foods. Previously, CFSs were shown to also improve linear growth and reduce stunting in this cohort. Findings support the need for CFSs in similar settings to promote nutritional well being and growth. This trial was registered at clinicaltrials.gov as NCT01562379.
Authors: Zaynah T Chowdhury; Kristen M Hurley; Rebecca K Campbell; Saijuddin Shaikh; Abu Ahmed Shamim; Sucheta Mehra; Parul Christian Journal: Curr Dev Nutr Date: 2020-07-15
Authors: Bess L Caswell; Charles D Arnold; Chessa K Lutter; Lora L Iannotti; Raphael Chipatala; Elizabeth Rochelle Werner; Kenneth M Maleta; Christine P Stewart Journal: Matern Child Nutr Date: 2021-05-11 Impact factor: 3.092
Authors: Kathryn G Dewey; K Ryan Wessells; Charles D Arnold; Elizabeth L Prado; Souheila Abbeddou; Seth Adu-Afarwuah; Hasmot Ali; Benjamin F Arnold; Per Ashorn; Ulla Ashorn; Sania Ashraf; Elodie Becquey; Jaden Bendabenda; Kenneth H Brown; Parul Christian; John M Colford; Sherlie J L Dulience; Lia C H Fernald; Emanuela Galasso; Lotta Hallamaa; Sonja Y Hess; Jean H Humphrey; Lieven Huybregts; Lora L Iannotti; Kaniz Jannat; Anna Lartey; Agnes Le Port; Jef L Leroy; Stephen P Luby; Kenneth Maleta; Susana L Matias; Mduduzi N N Mbuya; Malay K Mridha; Minyanga Nkhoma; Clair Null; Rina R Paul; Harriet Okronipa; Jean-Bosco Ouédraogo; Amy J Pickering; Andrew J Prendergast; Marie Ruel; Saijuddin Shaikh; Ann M Weber; Patricia Wolff; Amanda Zongrone; Christine P Stewart Journal: Am J Clin Nutr Date: 2021-11-02 Impact factor: 7.045
Authors: Chessa K Lutter; Bess L Caswell; Charles D Arnold; Lora L Iannotti; Kenneth Maleta; Raphael Chipatala; Elizabeth L Prado; Christine P Stewart Journal: Matern Child Nutr Date: 2020-07-20 Impact factor: 3.092