Ülkü Küçük1, Sümeyye Ekmekçi1, Ebru Çakır2, Zübeyde Ekin3, Batuhan Ergani4, Gökhan Rahmi Ekin5. 1. Department of Pathology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey. 2. Department of Pathology, University of Katip Çelebi, Atatürk Training and Research Hospital, İzmir, Turkey. 3. Department of Pathology, Ege University School of Medicine, İzmir, Turkey. 4. Department of Urology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey. 5. Department of Urology, Urla State Hospital, İzmir, Turkey.
Abstract
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of tumor budding in muscle invasive urothelial carcinoma of bladder (MIBC). MATERIAL AND METHODS: A total of 60 patients who underwent radical cystectomy and cystoprostatectomy for MIBC were included in the study. The correlations between tumor budding, and tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI) and histopathological data with distant metastasis were evaluated. The correlation between progression free (PFS) and overall survival (OS) rates and the presence, and grade of tumor budding was investigated. RESULTS: A statistically significant correlation was not seen between tumor budding, necrosis, LVI, and PNI. There was a strong correlation between distant organ metastasis, and presence of tumor necrosis. There was no statistically significant correlation between PFS, OS and tumor budding. A statistically significant relationship was observed between OS and tumor stage, lymph node metastasis, and distant organ metastasis. CONCLUSION: In our study, statistically significant effect of tumor budding on survival rates in MIBCs was not observed. Also, no significant correlation was observed between tumor budding and tumor necrosis, LVI, and PNI.
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of tumor budding in muscle invasive urothelial carcinoma of bladder (MIBC). MATERIAL AND METHODS: A total of 60 patients who underwent radical cystectomy and cystoprostatectomy for MIBC were included in the study. The correlations between tumor budding, and tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI) and histopathological data with distant metastasis were evaluated. The correlation between progression free (PFS) and overall survival (OS) rates and the presence, and grade of tumor budding was investigated. RESULTS: A statistically significant correlation was not seen between tumor budding, necrosis, LVI, and PNI. There was a strong correlation between distant organ metastasis, and presence of tumor necrosis. There was no statistically significant correlation between PFS, OS and tumor budding. A statistically significant relationship was observed between OS and tumor stage, lymph node metastasis, and distant organ metastasis. CONCLUSION: In our study, statistically significant effect of tumor budding on survival rates in MIBCs was not observed. Also, no significant correlation was observed between tumor budding and tumor necrosis, LVI, and PNI.
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