| Literature DB >> 30183292 |
Asuka Matsunami1, Kazuki Takizawa1, Shogo Sugano1, Yusuke Yano1, Hiroaki Sato1, Ryo Takeuchi1.
Abstract
A synthesis of chiral homoallylic nitriles by the iridium-catalyzed allylation of cyanoacetates followed by Krapcho demethoxycarbonylation has been developed. A wide range of homoallylic nitriles were obtained with a high enantioselectivity (>95-99% ee). These compounds are useful chiral building blocks because further synthetic elaboration starting from a nitrile or terminal alkene is possible.Entities:
Year: 2018 PMID： 30183292 DOI： 10.1021/acs.joc.8b01632
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354