| Literature DB >> 30183084 |
Min Liu1,2,3,4,5, Qian Sun1,2,3,4,5, Jian Wang1,2,3,4,5, Feng Wei1,2,3,4,5, Lili Yang1,2,3,4,5, Xiubao Ren1,2,3,4,5,6.
Abstract
Our previous understanding of the role of B lymphocytes in tumor immunity is its antitumor effects. However, further evidence indicates B lymphocytes can also promote tumorigenesis by modulating immune responses. Therefore, the increasingly complex role of B lymphocytes in tumor immunity may become an important factor in tumor immunotherapy. In this review, we describe the development of B cells in tumor microenvironments. We then focus on the most controversial issues of the biological functions of B lymphocytes. Finally, we nominate B cells as therapeutic targets, which should open broad perspectives for the development of their clinical applications.Entities:
Keywords: B lymphocytes; immunotherapy; prognosis; regulatory B cells; tumor immunity
Mesh：
Year: 2018 PMID： 30183084 DOI： 10.1002/ijc.31850
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396