Ju Young Jung1, Jae-Jun Shim2, Sung Keun Park1, Jae-Hong Ryoo3, Joong-Myung Choi4, In-Hwan Oh4, Kyu-Won Jung5, Hyunsoon Cho5,6, Moran Ki6, Young-Joo Won5,6, Chang-Mo Oh7. 1. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. 2. Departments of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. 3. Departments of Occupation and Environmental medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. 4. Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. 5. Cancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea. 6. Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea. 7. Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. kachas@naver.com.
Abstract
BACKGROUND: Elevation of serum ferritin levels is frequently observed in non-alcoholic fatty liver disease (NAFLD) patients. Our study aims to examine the association between serum ferritin levels and NAFLD in Korean population. METHODS AND RESULTS: A total of 25,597 participants were selected from Korean National Health and Nutritional Examination Surveys 2007-2012. The NAFLD liver fat score (NLFS) was used to define NAFLD. Elevation of ALT levels was defined as ALT level > 40 IU/L for male and ALT level > 31 IU/L for female. Multiple logistic regression was used to examine the association of serum ferritin levels and NAFLD by sex. After adjusting for multiple covariates, the ORs (95% CI) of the elevated ALT levels were 1.56 (95% CI: 1.17-2.07), 1.84 (95% CI: 1.39-2.45), and 4.08 (95% CI: 3.08-5.40) for the second, third and fourth serum ferritin quartiles in male (p for trend < 0.01), 1.67 (95% CI: 1.24-2.23), 2.23 (95% CI: 1.68-2.96), and 5.72 (95% CI: 4.32-7.60) for the second, third and fourth serum ferritin quartiles in female (p for trend < 0.01). Serum ferritin levels were also significantly associated with NAFLD and liver fibrosis both in male and female. CONCLUSIONS: Elevation of serum ferritin level is significantly associated with NAFLD and blood ALT elevation in Korean general population.
BACKGROUND: Elevation of serum ferritin levels is frequently observed in non-alcoholic fatty liver disease (NAFLD) patients. Our study aims to examine the association between serum ferritin levels and NAFLD in Korean population. METHODS AND RESULTS: A total of 25,597 participants were selected from Korean National Health and Nutritional Examination Surveys 2007-2012. The NAFLD liver fat score (NLFS) was used to define NAFLD. Elevation of ALT levels was defined as ALT level > 40 IU/L for male and ALT level > 31 IU/L for female. Multiple logistic regression was used to examine the association of serum ferritin levels and NAFLD by sex. After adjusting for multiple covariates, the ORs (95% CI) of the elevated ALT levels were 1.56 (95% CI: 1.17-2.07), 1.84 (95% CI: 1.39-2.45), and 4.08 (95% CI: 3.08-5.40) for the second, third and fourth serum ferritin quartiles in male (p for trend < 0.01), 1.67 (95% CI: 1.24-2.23), 2.23 (95% CI: 1.68-2.96), and 5.72 (95% CI: 4.32-7.60) for the second, third and fourth serum ferritin quartiles in female (p for trend < 0.01). Serum ferritin levels were also significantly associated with NAFLD and liver fibrosis both in male and female. CONCLUSIONS: Elevation of serum ferritin level is significantly associated with NAFLD and blood ALT elevation in Korean general population.
Authors: Eric Slywitch; Carine Savalli; Antonio Cláudio Duarte; Maria Arlete Meil Schimith Escrivão Journal: Nutrients Date: 2022-05-26 Impact factor: 6.706