Literature DB >> 30182093

Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents.

Wei Fan1, Wenting Zhang, Sameer Alshehri, Jered C Garrison.   

Abstract

We report a strategy of utilizing irreversible cysteine cathepsin inhibitor as trapping agent to increase the tumor residence time of receptor-targeted agents. The targeted constructs incorporating these cysteine cathepsin trapping agents were able to form high molecular weight adducts with intracellular cysteine cathepsins, thus achieving superior retention in tumor tissues.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 30182093      PMCID： PMC6181586          DOI： 10.1039/c8cc05982a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

Review 1.  Specialized roles for cysteine cathepsins in health and disease.

Authors:  Jochen Reiser; Brian Adair; Thomas Reinheckel
Journal:  J Clin Invest       Date:  2010-10-01       Impact factor: 14.808

Review 2.  Cathepsin L targeting in cancer treatment.

Authors:  Dhivya R Sudhan; Dietmar W Siemann
Journal:  Pharmacol Ther       Date:  2015-08-20       Impact factor: 12.310

3.  Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

Authors:  Galia Blum; Georges von Degenfeld; Milton J Merchant; Helen M Blau; Matthew Bogyo
Journal:  Nat Chem Biol       Date:  2007-09-09       Impact factor: 15.040

4.  Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases.

Authors:  A Krantz; L J Copp; P J Coles; R A Smith; S B Heard
Journal:  Biochemistry       Date:  1991-05-14       Impact factor: 3.162

Review 5.  Peptide-based radiopharmaceuticals and cytotoxic conjugates: potential tools against cancer.

Authors:  S M Okarvi
Journal:  Cancer Treat Rev       Date:  2007-09-17       Impact factor: 12.111

Review 6.  Cysteine cathepsin proteases as pharmacological targets in cancer.

Authors:  Carmela Palermo; Johanna A Joyce
Journal:  Trends Pharmacol Sci       Date:  2007-11-26       Impact factor: 14.819

Review 7.  The current stage of cathepsin B inhibitors as potential anticancer agents.

Authors:  Janko Kos; Ana Mitrović; Bojana Mirković
Journal:  Future Med Chem       Date:  2014-07       Impact factor: 3.808

8.  Radiolabeled peptides: valuable tools for the detection and treatment of cancer.

Authors:  M Fani; H R Maecke; S M Okarvi
Journal:  Theranostics       Date:  2012-05-16       Impact factor: 11.556

9.  Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice.

Authors:  Erik Vegt; Marleen Melis; Annemarie Eek; Monique de Visser; Maarten Brom; Wim J G Oyen; Martin Gotthardt; Marion de Jong; Otto C Boerman
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-12-18       Impact factor: 9.236

Review 10.  Cysteine cathepsins: from structure, function and regulation to new frontiers.

Authors:  Vito Turk; Veronika Stoka; Olga Vasiljeva; Miha Renko; Tao Sun; Boris Turk; Dušan Turk
Journal:  Biochim Biophys Acta       Date:  2011-10-12
View more
  2 in total

1.  Enhanced tumor retention of NTSR1-targeted agents by employing a hydrophilic cysteine cathepsin inhibitor.

Authors:  Wei Fan; Wenting Zhang; Sameer Alshehri; Trey R Neeley; Jered C Garrison
Journal:  Eur J Med Chem       Date:  2019-05-25       Impact factor: 6.514

2.  Examination of the impact molecular charge has on NTSR1-targeted agents incorporated with cysteine protease inhibitors.

Authors:  Wei Fan; Wenting Zhang; Sameer Alshehri; Jered C Garrison
Journal:  Eur J Med Chem       Date:  2022-03-08       Impact factor: 6.514
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.