Zhisen Gao1, Yinqiao Du1, Shang Piao1, Jingyang Sun1, Xiang Li1, Yonggang Zhou2. 1. The General Hospital of Chinese People's Liberation Army, No.28 of Fuxing Road, Haidian District, Beijing, 100853, China. 2. The General Hospital of Chinese People's Liberation Army, No.28 of Fuxing Road, Haidian District, Beijing, 100853, China. Electronic address: Zhouyg@263.net.
Abstract
BACKGROUND: Staphylococcus species are major pathogens of peri-prosthetic joint infection (PJI). Coagulase-positive staphylococci and coagulase-negative staphylococci have different intrinsic virulences. However, few studies have specifically compared the clinical manifestations and two-stage revision outcomes of PJI caused by these two species. METHODS: We retrospectively collected 260 arthroplasty patients who underwent a two-stage revision because of PJI from January 2003 to June 2015 in our institute because of PJI. Sixty-four patients (36 hips and 28 knees) and 23 patients (13 hips and 10 knees) were infected by coagulase-negative staphylococci (CoNS) and SA, respectively. RESULTS: The preoperative mean ESR value of the SA group was higher than that of the CoNS group (median, 60.9 VS 35.9; P < 0.001). Seventeen (73.9%) of the 23 SA infected patients had a sinus tract, while only 12 (18.8%) of the 64 CoNS-infected patients had this symptom (73.9% VS 18.8%; P < 0.001). At the time of follow-up, 58 (90.6%) of the 64 CoNS-infected patients had successfully controlled the infection. In the SA group, 20 (87.0%) patients ultimately acquired successful control (90.6% VS 87.0%; P = 0.923). Surgical history was identified as a potential risk factor (OR = 6.2, 95%CI 1.17-32.4) for prognosis when potential covariates were adjusted. CONCLUSIONS: SA infection has a higher ESR value and a more frequent occurrence of sinus tract. The infection control rate of the two-stage revision protocol was close to 90% for both SA and CoNS species, and there is no statistically significant difference in the eradication rate of infection between the SA and CoNS groups. Surgical history may be a good predictor of failure for PJI patients treated with two-stage revision.
BACKGROUND: Staphylococcus species are major pathogens of peri-prosthetic joint infection (PJI). Coagulase-positive staphylococci and coagulase-negative staphylococci have different intrinsic virulences. However, few studies have specifically compared the clinical manifestations and two-stage revision outcomes of PJI caused by these two species. METHODS: We retrospectively collected 260 arthroplasty patients who underwent a two-stage revision because of PJI from January 2003 to June 2015 in our institute because of PJI. Sixty-four patients (36 hips and 28 knees) and 23 patients (13 hips and 10 knees) were infected by coagulase-negative staphylococci (CoNS) and SA, respectively. RESULTS: The preoperative mean ESR value of the SA group was higher than that of the CoNS group (median, 60.9 VS 35.9; P < 0.001). Seventeen (73.9%) of the 23 SAinfectedpatients had a sinus tract, while only 12 (18.8%) of the 64 CoNS-infectedpatients had this symptom (73.9% VS 18.8%; P < 0.001). At the time of follow-up, 58 (90.6%) of the 64 CoNS-infectedpatients had successfully controlled the infection. In the SA group, 20 (87.0%) patients ultimately acquired successful control (90.6% VS 87.0%; P = 0.923). Surgical history was identified as a potential risk factor (OR = 6.2, 95%CI 1.17-32.4) for prognosis when potential covariates were adjusted. CONCLUSIONS:SA infection has a higher ESR value and a more frequent occurrence of sinus tract. The infection control rate of the two-stage revision protocol was close to 90% for both SA and CoNS species, and there is no statistically significant difference in the eradication rate of infection between the SA and CoNS groups. Surgical history may be a good predictor of failure for PJI patients treated with two-stage revision.