| Literature DB >> 3018092 |
C R Rinaldo, L A Kingsley, D W Lyter, B S Rabin, R W Atchison, A J Bodner, S H Weiss, W C Saxinger.
Abstract
Homosexual men were studied for associations among human T-lymphotropic virus type III (HTLV-III) infection, Epstein-Barr virus (EBV) infection, and T cell abnormalities. The presence of IgG antibody to EBV capsid antigen and antibody to EBV early antigen was significantly associated with augmented counts of suppressor T cells in healthy HTLV-III-seronegative men. HTLV-III-seropositive asymptomatic subjects had significantly enhanced titers of antibody to EBV and lower ratios of helper to suppressor T cells compared with HTLV-III-seronegative homosexual men. Of three men who seroconverted to HTLV-III, two had a greater than fourfold increase in titer of IgG antibody to EBV capsid antigen after seroconversion. These results suggest that the interaction of HTLV-III and EBV and their immunologic perturbations are significant in the natural history of this retrovirus infection in homosexual men.Entities:
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Year: 1986 PMID： 3018092 DOI： 10.1093/infdis/154.4.556
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226