Joel H Rubenstein1,2,3, Daniel McConnell4, David G Beer5, Amitabh Chak6, Valbona Metko2, Gregory Clines3,7. 1. Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center. 2. Department of Internal Medicine, Division of Gastroenterology. 3. Veterans Affairs Ann Arbor Medical Center. 4. University of Michigan School of Public Health, Ann Arbor, MI. 5. Department of Surgery, Thoracic Surgery. 6. Case Western Reserve University Medical School, Cleveland, OH. 7. Department of Internal Medicine, Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School.
Abstract
BACKGROUND: Esophageal adenocarcinoma has been inversely associated with exposure to ultraviolet radiation. This could be because of vitamin D deficiency or hyperparathyroidism promoting gastroesophageal reflux disease (GERD) and Barrett's esophagus. AIM: The aim of this study is to determine the association between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett's esophagus. METHODS: We assayed banked serum for PTH and total 25-hydroxy vitamin D from a cross-sectional cohort. Logistic regression was performed to estimate the associations of vitamin D deficiency and hyperparathyroidism with GERD symptoms, erosive esophagitis, and Barrett's esophagus. RESULTS: Sera from 605 men were assayed, including 150 with GERD, 216 with erosive esophagitis, 145 with Barrett's esophagus, and 174 normal subjects. Contrary to our hypothesis, we found a strong inverse association between Barrett's esophagus and hyperparathyroidism (odds ratio=0.516; 95% confidence interval=0.265, 1.01), and a trend toward an inverse association with vitamin D deficiency. We found no association between vitamin D deficiency or hyperparathyroidism with GERD symptoms or erosive esophagitis. CONCLUSIONS: Contrary to our hypothesis, we found an inverse association between serum PTH and Barrett's esophagus. Validation of the finding and the mechanism of that association deserves further study.
BACKGROUND: Esophageal adenocarcinoma has been inversely associated with exposure to ultraviolet radiation. This could be because of vitamin D deficiency or hyperparathyroidism promoting gastroesophageal reflux disease (GERD) and Barrett's esophagus. AIM: The aim of this study is to determine the association between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett's esophagus. METHODS: We assayed banked serum for PTH and total 25-hydroxy vitamin D from a cross-sectional cohort. Logistic regression was performed to estimate the associations of vitamin D deficiency and hyperparathyroidism with GERD symptoms, erosive esophagitis, and Barrett's esophagus. RESULTS: Sera from 605 men were assayed, including 150 with GERD, 216 with erosive esophagitis, 145 with Barrett's esophagus, and 174 normal subjects. Contrary to our hypothesis, we found a strong inverse association between Barrett's esophagus and hyperparathyroidism (odds ratio=0.516; 95% confidence interval=0.265, 1.01), and a trend toward an inverse association with vitamin D deficiency. We found no association between vitamin D deficiency or hyperparathyroidism with GERD symptoms or erosive esophagitis. CONCLUSIONS: Contrary to our hypothesis, we found an inverse association between serum PTH and Barrett's esophagus. Validation of the finding and the mechanism of that association deserves further study.
Authors: Eamonn M M Quigley; Brian C Jacobson; Johannes Lenglinger; Joel H Rubenstein; Hashem El-Serag; Michele Cicala; Richard W McCallum; Marc S Levine; Richard M Gore Journal: Ann N Y Acad Sci Date: 2011-09 Impact factor: 5.691
Authors: Joel H Rubenstein; Hal Morgenstern; Daniel McConell; James M Scheiman; Philip Schoenfeld; Henry Appelman; Laurence F McMahon; John Y Kao; Val Metko; Min Zhang; John M Inadomi Journal: Gastroenterology Date: 2013-08-30 Impact factor: 22.682
Authors: Christian C Abnet; Yu Chen; Wong-Ho Chow; Yu-Tang Gao; Kathy J Helzlsouer; Loïc Le Marchand; Marjorie L McCullough; James M Shikany; Jarmo Virtamo; Stephanie J Weinstein; Yong-Bing Xiang; Kai Yu; Wei Zheng; Demetrius Albanes; Alan A Arslan; David S Campbell; Peter T Campbell; Richard B Hayes; Ronald L Horst; Laurence N Kolonel; Abraham M Y Nomura; Mark P Purdue; Kirk Snyder; Xiao-Ou Shu Journal: Am J Epidemiol Date: 2010-06-18 Impact factor: 4.897
Authors: Joel H Rubenstein; Hal Morgenstern; Henry Appelman; James Scheiman; Philip Schoenfeld; Laurence F McMahon; Valbona Metko; Ellen Near; Joan Kellenberg; Tal Kalish; John M Inadomi Journal: Am J Gastroenterol Date: 2013-01-15 Impact factor: 10.864
Authors: Joel H Rubenstein; Hal Morgenstern; William D Chey; Joseph Murray; James M Scheiman; Philip Schoenfeld; Henry D Appelman; Laurence McMahon; Val Metko; Joan Kellenberg; Tal Kalish; Jason Baker; John M Inadomi Journal: Gut Date: 2013-03-05 Impact factor: 23.059