Chiara Zavanone1, Yves Samson2, Céline Arbizu3, Sophie Dupont4, Didier Dormont5, Charlotte Rosso6. 1. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; ARAMIS, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; APHP, Neurological Rehabilitation Unit, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. Electronic address: chiara.zavanone@aphp.fr. 2. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; ARAMIS, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; UPMC Paris Sorbonne Université, Paris, France. Electronic address: yves.samson@aphp.fr. 3. APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; Centre des Maladies Cognitives et Comportementales, IM2A, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. Electronic address: celine.arbizu@aphp.fr. 4. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; ARAMIS, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; APHP, Neurological Rehabilitation Unit, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; UPMC Paris Sorbonne Université, Paris, France. Electronic address: sophie.dupont@aphp.fr. 5. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; ARAMIS, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; UPMC Paris Sorbonne Université, Paris, France; APHP, Department of Neuroradiology, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. Electronic address: didier.dormont@aphp.fr. 6. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; UPMC Paris Sorbonne Université, Paris, France; Control of Normal and Abnormal Movement: Physiopathology and Experimental Therapeutics, UPMC Paris 6, Inserm, U1127, CNRS, UMR 7225, Paris, France. Electronic address: charlotte.rosso@aphp.fr.
Abstract
OBJECTIVES: To identify the critical brain regions associated with 7-days, 3 and 6-months aphasia severity using diffusion-weighted imaging (DWI) in acute post-stroke patients. MATERIALS AND METHODS: We performed a voxel-based ADC (Apparent Diffusion Coefficient) analysis to identify the critical brain areas correlated with aphasia at the acute (7-days outcome) and chronic stages (3 and 6-months). The location of these areas was compared with the trajectory of the dorsal (the arcuate fasciculus) and the ventral language pathways (the inferior fronto-occipital and the uncinate fasciculi). RESULTS: Disconnections of the language fasciculi, which were correlated with aphasia outcome, were not the same for the 7-days outcome (disconnection of the ventral stream) and the chronic outcome (3 and 6 months) (disconnection of the dorsal and ventral streams). CONCLUSION: Routine clinical images can be merged with atlases of anatomical connectivity to provide new insights about the relationship between the lesion location and aphasia severity.
OBJECTIVES: To identify the critical brain regions associated with 7-days, 3 and 6-months aphasia severity using diffusion-weighted imaging (DWI) in acute post-strokepatients. MATERIALS AND METHODS: We performed a voxel-based ADC (Apparent Diffusion Coefficient) analysis to identify the critical brain areas correlated with aphasia at the acute (7-days outcome) and chronic stages (3 and 6-months). The location of these areas was compared with the trajectory of the dorsal (the arcuate fasciculus) and the ventral language pathways (the inferior fronto-occipital and the uncinate fasciculi). RESULTS: Disconnections of the language fasciculi, which were correlated with aphasia outcome, were not the same for the 7-days outcome (disconnection of the ventral stream) and the chronic outcome (3 and 6 months) (disconnection of the dorsal and ventral streams). CONCLUSION: Routine clinical images can be merged with atlases of anatomical connectivity to provide new insights about the relationship between the lesion location and aphasia severity.
Authors: Sigfus Kristinsson; Dirk B den Ouden; Chris Rorden; Roger Newman-Norlund; Jean Neils-Strunjas; Julius Fridriksson Journal: J Stroke Date: 2022-05-31 Impact factor: 8.632