Evangelia Liouta1, Vasileios K Katsaros2, George Stranjalis3, Edyta Leks4, Uwe Klose5, Sotirios Bisdas6. 1. Department of Neurosurgery, University of Athens, "Evangelismos" Hospital, Athens, Greece; Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany. Electronic address: evangelialiouta286@hotmail.com. 2. Department of Radiology, General Anti-Cancer and Oncological Hospital of Athens "St. Savvas", Athens, Greece; Department of Neurosurgery, University of Athens, "Evangelismos" Hospital, Athens, Greece; Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany. 3. Department of Neurosurgery, University of Athens, "Evangelismos" Hospital, Athens, Greece. 4. Department of Biomedical Magnetic Resonance, University Hospital of Tübingen, Tübingen, Germany. 5. Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany. 6. Department of Neuroradiology, University Hospital of Tübingen, Tübingen, Germany; Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK; Institute of Neurology, University College London, London, UK.
Abstract
BACKGROUND AND PURPOSE: Evidence of pre-operative resting state functional magnetic resonance (RS-fMRI) validation by correlating it with clinical pre-operative status in brain tumor patients is scarce. Our aim was to validate the functional relevance of RS-fMRI by investigating the association between RS-fMRI and pre-operative motor and language function performance in patients with brain tumor. MATERIALS AND METHODS: Sixty-nine patients with brain tumors were prospectively recruited. Patients with tumors near precentral gyrus (n = 49) underwent assessment for apparent (paresis) and subtle (finger tapping) deficits. Patients with left frontal tumors in the vicinity of the inferior frontal gyrus (n = 29) underwent assessment for gross (aphasia) and mild language (phonological verbal fluency) deficits. RS-fMRI results were extracted by spatial independent component analysis (ICA). RESULTS: Motor group: paretic patients showed significantly (P = 0.01) decreased BOLD signal in ipsilesional precentral gyrus when compared to contralesional one. Significantly (P < 0.01) lower BOLD signal was also observed in ipsilesional precentral gyrus of paretics when compared with the non-paretics. In asymptomatic patients, a strong positive correlation (r = 0.68, P < 0.01) between ipsilesional motor cortex BOLD signal and contralesional finger tapping performance was observed. Language group: patients with aphasia showed significantly (P = 0.01) decreased RS-fMRI BOLD signal in left BA 44 when compared with non- aphasics. In asymptomatic patients, a strong positive correlation (r = 0.72, P < 0.01) between BA 44 BOLD signal and phonological fluency performance was observed. CONCLUSIONS: Our results showed that RS-fMRI BOLD signal of motor and language networks were significantly affected by the tumors implying the usefulness of the method for assessment of the underlying functions in brain tumors patients.
BACKGROUND AND PURPOSE: Evidence of pre-operative resting state functional magnetic resonance (RS-fMRI) validation by correlating it with clinical pre-operative status in brain tumorpatients is scarce. Our aim was to validate the functional relevance of RS-fMRI by investigating the association between RS-fMRI and pre-operative motor and language function performance in patients with brain tumor. MATERIALS AND METHODS: Sixty-nine patients with brain tumors were prospectively recruited. Patients with tumors near precentral gyrus (n = 49) underwent assessment for apparent (paresis) and subtle (finger tapping) deficits. Patients with left frontal tumors in the vicinity of the inferior frontal gyrus (n = 29) underwent assessment for gross (aphasia) and mild language (phonological verbal fluency) deficits. RS-fMRI results were extracted by spatial independent component analysis (ICA). RESULTS: Motor group: paretic patients showed significantly (P = 0.01) decreased BOLD signal in ipsilesional precentral gyrus when compared to contralesional one. Significantly (P < 0.01) lower BOLD signal was also observed in ipsilesional precentral gyrus of paretics when compared with the non-paretics. In asymptomatic patients, a strong positive correlation (r = 0.68, P < 0.01) between ipsilesional motor cortex BOLD signal and contralesional finger tapping performance was observed. Language group: patients with aphasia showed significantly (P = 0.01) decreased RS-fMRI BOLD signal in left BA 44 when compared with non- aphasics. In asymptomatic patients, a strong positive correlation (r = 0.72, P < 0.01) between BA 44 BOLD signal and phonological fluency performance was observed. CONCLUSIONS: Our results showed that RS-fMRI BOLD signal of motor and language networks were significantly affected by the tumors implying the usefulness of the method for assessment of the underlying functions in brain tumorspatients.
Authors: Kostakis Gkiatis; Kyriakos Garganis; Christopher F Benjamin; Irene Karanasiou; Nikolaos Kondylidis; Jean Harushukuri; George K Matsopoulos Journal: Brain Behav Date: 2022-05-19 Impact factor: 3.405
Authors: Nicholas S Cho; Kyung K Peck; Madeleine N Gene; Mehrnaz Jenabi; Andrei I Holodny Journal: Brain Imaging Behav Date: 2021-08-01 Impact factor: 3.224