Literature DB >> 30179492

Discovery of Plant Growth Stimulants by C-H Arylation of 2-Azahypoxanthine.

Hiroyuki Kitano1, Jae-Hoon Choi2, Ayaka Ueda1, Hideto Ito1,3, Shinya Hagihara1,4, Toshiyuki Kan5, Hirokazu Kawagishi2,6, Kenichiro Itami1,3.   

Abstract

A series of new AHX derivatives were synthesized by Pd-catalyzed C-H arylation. Their rice-growth-promoting activity was evaluated in vivo. Among the synthesized compounds, C8 phenyl-substituted AHX showed remarkable growth-promoting activity on rice. The present study shows the power and significant opportunity of C-H functionalization chemistry to rapidly transform biologically active natural products into more active compounds.

Entities:  

Year:  2018        PMID: 30179492     DOI: 10.1021/acs.orglett.8b02407

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Plant growth regulators from mushrooms.

Authors:  Jing Wu; Hirokazu Kawagishi
Journal:  J Antibiot (Tokyo)       Date:  2020-07-20       Impact factor: 2.649

2.  A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice.

Authors:  Hirohide Takemura; Jae-Hoon Choi; Nobuo Matsuzaki; Yuki Taniguchi; Jing Wu; Hirofumi Hirai; Reiko Motohashi; Tomohiro Asakawa; Kazutada Ikeuchi; Makoto Inai; Toshiyuki Kan; Hirokazu Kawagishi
Journal:  Sci Rep       Date:  2019-07-09       Impact factor: 4.379

  2 in total

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