INTRODUCTION AND OBJECTIVES: Thoracic aortic dissection (TAD) is infrequent in young people and its characteristics differ from those in the adult population. This study aimed to analyze the clinical and pathological characteristics of sudden death due to TAD in people aged 1 to 35 years. METHODS: Multicenter population-based study based on forensic autopsies conducted in the provinces of Biscay (1991-2016), Valencia (2000-2016), and Seville (2004-2016). RESULTS: We identified 35 individuals with sudden death due to TAD (80% males), with a mean age of 29±5 years. The incidence was 0.09/100 000 inhabitants/y. Eighteen persons had at least 1 risk factor for TAD, and this figure increased to 29 when postmortem findings were included: congenital heart disease (n=16), suspicion of familial TAD (n=11), cocaine use (n=6), and hypertension (n=5). Twenty-four individuals, 12 with at least 1 risk factor, had prodromal symptoms, and 16 of them visited their physician, but TAD was not suspected in any of them. The most frequent symptom was chest pain (n=12). The main autopsy findings were cystic degeneration of the media (n=27), dilatation of the ascending aorta (n=21), cardiac hypertrophy (n=20), and bicuspid aortic valve (n=14). CONCLUSIONS: The incidence of sudden death due to TAD in young people was very low. The most frequent risk factors were congenital heart disease followed by suspicion of familial TAD and cocaine use. TAD should be included in the differential diagnosis of chest pain in young people, mainly male patients with at least 1 risk factor.
INTRODUCTION AND OBJECTIVES: Thoracic aortic dissection (TAD) is infrequent in young people and its characteristics differ from those in the adult population. This study aimed to analyze the clinical and pathological characteristics of sudden death due to TAD in people aged 1 to 35 years. METHODS: Multicenter population-based study based on forensic autopsies conducted in the provinces of Biscay (1991-2016), Valencia (2000-2016), and Seville (2004-2016). RESULTS: We identified 35 individuals with sudden death due to TAD (80% males), with a mean age of 29±5 years. The incidence was 0.09/100 000 inhabitants/y. Eighteen persons had at least 1 risk factor for TAD, and this figure increased to 29 when postmortem findings were included: congenital heart disease (n=16), suspicion of familial TAD (n=11), cocaine use (n=6), and hypertension (n=5). Twenty-four individuals, 12 with at least 1 risk factor, had prodromal symptoms, and 16 of them visited their physician, but TAD was not suspected in any of them. The most frequent symptom was chest pain (n=12). The main autopsy findings were cystic degeneration of the media (n=27), dilatation of the ascending aorta (n=21), cardiac hypertrophy (n=20), and bicuspid aortic valve (n=14). CONCLUSIONS: The incidence of sudden death due to TAD in young people was very low. The most frequent risk factors were congenital heart disease followed by suspicion of familial TAD and cocaine use. TAD should be included in the differential diagnosis of chest pain in young people, mainly male patients with at least 1 risk factor.
Authors: Walter E M Rocha; Matheus F R A Oliveira; Julia D Soares; Victor M F S L'Armée; Mayara P G Martins; Aloísio M Rocha; Audes D M Feitosa; Ricardo C Lima; Pedro P M Oliveira; Lindemberg M Silveira-Filho; Otavio R Coelho-Filho; José R Matos-Souza; Orlando Petrucci; Andrei C Sposito; Wilson Nadruz Journal: J Am Heart Assoc Date: 2021-02-18 Impact factor: 5.501
Authors: Carlos Ferrera; Isidre Vilacosta; Beatriz Cabeza; Javier Cobiella; Isaac Martínez; Melchor Saiz-Pardo Sanz; Ana Bustos; Francisco Javier Serrano; Luis Maroto Journal: Vasc Health Risk Manag Date: 2020-06-08
Authors: Matheus F R A Oliveira; Walter E M Rocha; Julia D Soares; Victor M F S L'Armée; Mayara P G Martins; Aloísio M Rocha; Audes D M Feitosa; Ricardo C Lima; Pedro P M Oliveira; Lindemberg M Silveira-Filho; Otavio R Coelho-Filho; José R Matos-Souza; Orlando Petrucci; Andrei C Sposito; Wilson Nadruz Journal: Front Cardiovasc Med Date: 2022-01-21