Literature DB >> 3017729

Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol.

A J Hiltunen, T U Järbe.   

Abstract

Interaction effects of cannabidiol (CBD) and cannabinol (CBN) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) and vehicle (2 ml/kg). The generalization effects of CBN to delta 9-THC were attenuated when CBN was administered together with CBD. The results were time- and dose-dependent.

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Year:  1986        PMID： 3017729     DOI： 10.1016/0014-2999(86)90042-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984-1987.

Authors:  I P Stolerman; F Rasul; P J Shine
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons.

Authors:  Alex Straiker; Michaela Dvorakova; Anaelle Zimmowitch; Ken Mackie
Journal:  Mol Pharmacol       Date:  2018-04-18       Impact factor: 4.436

3.  Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.

Authors:  Sean D McAllister; Ryuichi Murase; Rigel T Christian; Darryl Lau; Anne J Zielinski; Juanita Allison; Carolina Almanza; Arash Pakdel; Jasmine Lee; Chandani Limbad; Yong Liu; Robert J Debs; Dan H Moore; Pierre-Yves Desprez
Journal:  Breast Cancer Res Treat       Date:  2010-09-22       Impact factor: 4.872

4.  Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol.

Authors:  Robert E Vann; Thomas F Gamage; Jonathan A Warner; Ericka M Marshall; Nathan L Taylor; Billy R Martin; Jenny L Wiley
Journal:  Drug Alcohol Depend       Date:  2008-04-01       Impact factor: 4.492

Review 5.  Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg.

Authors:  Gianluigi Tanda
Journal:  Psychopharmacology (Berl)       Date:  2016-03-30       Impact factor: 4.530
  5 in total

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