H Titou1, N Baba2, J Kasouati3, S Oumakir2, R Frikh2, M Boui2, N Hjira2. 1. Service de dermatologie vénérologie, hôpital militaire d'instruction Mohamed V, université Mohammed V de Rabat, 10100 Hay Ryad, Maroc. Electronic address: titou.medic@gmail.com. 2. Service de dermatologie vénérologie, hôpital militaire d'instruction Mohamed V, université Mohammed V de Rabat, 10100 Hay Ryad, Maroc. 3. Laboratoire de biostatistique et recherches cliniques et épidémiologique, FMPR, université Mohammed V de Rabat, Rabat, Maroc.
Abstract
BACKGROUND: The purpose was to study factors associated with the survival of HIV-1 patients receiving antiretroviral therapy in Morocco. MATERIAL AND METHOD: This was a retrospective study of a cohort of 182 HIV-1 patients receiving antiretroviral therapy in the department of dermatology venereology at the Military Instruction Hospital Mohamed V in Rabat during the period from 1 January 2006 to 1 January 2017. Death of any cause during the study period was considered to be the result of HIV infection. The log-rank test was used to compare the survival curves based on determinants. The Cox regression model analyzed the determinants of survival since induction of antiretroviral therapy. RESULTS: The median follow-up time was 4.7 years (IQR: 1.97-8.18). The mortality rate was 75 deaths per 1000 person-years. Advanced clinical stage CDC C (RR: 2.72; CI 95%: 1.33-5.56) and treatment with indinavir (RR: 1.41; CI 95%: 0.77-2.59) were significantly associated with death. CONCLUSION: Initiation of antiretroviral therapy in the early stage of the disease and use of less toxic molecules are recommended to reduce mortality.
BACKGROUND: The purpose was to study factors associated with the survival of HIV-1patients receiving antiretroviral therapy in Morocco. MATERIAL AND METHOD: This was a retrospective study of a cohort of 182 HIV-1patients receiving antiretroviral therapy in the department of dermatology venereology at the Military Instruction Hospital Mohamed V in Rabat during the period from 1 January 2006 to 1 January 2017. Death of any cause during the study period was considered to be the result of HIV infection. The log-rank test was used to compare the survival curves based on determinants. The Cox regression model analyzed the determinants of survival since induction of antiretroviral therapy. RESULTS: The median follow-up time was 4.7 years (IQR: 1.97-8.18). The mortality rate was 75 deaths per 1000 person-years. Advanced clinical stage CDC C (RR: 2.72; CI 95%: 1.33-5.56) and treatment with indinavir (RR: 1.41; CI 95%: 0.77-2.59) were significantly associated with death. CONCLUSION: Initiation of antiretroviral therapy in the early stage of the disease and use of less toxic molecules are recommended to reduce mortality.