Chomaw Sitotaw1, Fikir Asrie2, Mulugeta Melku3. 1. Section of Hematology, University of Gondar Referral Hospital Laboratory, University of Gondar, Gondar, Ethiopia. 2. Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. 3. Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: mulugeta.melku@gmail.com.
Abstract
OBJECTIVE: To evaluate platelet and White cell parameters in women with preeclampsia (PE) in comparison with a healthy pregnancy. METHODS: A cross-sectional study was carried in 2015 at University of Gondar hospital. Thirty-three mild PE, 30 severe PE cases and 63 healthy pregnant women were enrolled in the study. About 3 mL venous blood sample was collected from each study participants. Hematological parameters were determined by Sysmex KX-21 hematological analyzer. Data normality was checked by Kolmogorov-Smirnov normality test. One way analysis of variance with Bonferroni test and Pearson's product moment correlation were done for normally distributed data. For non-normally distributed data, Kruskal-Wallis H test with the Mann-Whitney U test and Spearman's rank-order Correlation test were done using SPSS 20.0 for Windows. A p-value <0.05 was considered as statistically significant. RESULTS: The means of white blood cells (WBC), absolute Neutrophil count (ANC), Absolute middle cell count (AMC), mean Platelet count (PTC), Platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), and median of platelet-to-large cell ratio (P-LCR) were significantly increased; while Absolute lymphocyte count (ALC) and platelet count (PTC) were significantly decreased in PE groups. WBC, ANC, MPV, PDW, P-LCR and NLR showed statistically significant positive correlations, whereas PTC displayed a statistically significant negative correlation with a MAP in PE group. CONCLUSION: WBC, ANC, MPV, PDW, P-LCR and NLR were increased as PE advanced. PTC decreased with the severity of the disease. Evaluation of these parameters as a supportive clinical marker in the assessment of severity may assist the management of PE.
OBJECTIVE: To evaluate platelet and White cell parameters in women with preeclampsia (PE) in comparison with a healthy pregnancy. METHODS: A cross-sectional study was carried in 2015 at University of Gondar hospital. Thirty-three mild PE, 30 severe PE cases and 63 healthy pregnant women were enrolled in the study. About 3 mL venous blood sample was collected from each study participants. Hematological parameters were determined by Sysmex KX-21 hematological analyzer. Data normality was checked by Kolmogorov-Smirnov normality test. One way analysis of variance with Bonferroni test and Pearson's product moment correlation were done for normally distributed data. For non-normally distributed data, Kruskal-Wallis H test with the Mann-Whitney U test and Spearman's rank-order Correlation test were done using SPSS 20.0 for Windows. A p-value <0.05 was considered as statistically significant. RESULTS: The means of white blood cells (WBC), absolute Neutrophil count (ANC), Absolute middle cell count (AMC), mean Platelet count (PTC), Platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), and median of platelet-to-large cell ratio (P-LCR) were significantly increased; while Absolute lymphocyte count (ALC) and platelet count (PTC) were significantly decreased in PE groups. WBC, ANC, MPV, PDW, P-LCR and NLR showed statistically significant positive correlations, whereas PTC displayed a statistically significant negative correlation with a MAP in PE group. CONCLUSION: WBC, ANC, MPV, PDW, P-LCR and NLR were increased as PE advanced. PTC decreased with the severity of the disease. Evaluation of these parameters as a supportive clinical marker in the assessment of severity may assist the management of PE.
Authors: Shilong Li; Zichen Wang; Luciana A Vieira; Amanda B Zheutlin; Boshu Ru; Emilio Schadt; Pei Wang; Alan B Copperman; Joanne L Stone; Susan J Gross; Yu-Han Kao; Yan Kwan Lau; Siobhan M Dolan; Eric E Schadt; Li Li Journal: NPJ Digit Med Date: 2022-06-06
Authors: Bjoern F Kraemer; Irina Hennis; Anne Karge; Anne Katrin Kraemer; Tobias F Dreyer; Marion Kiechle; Bettina Kuschel; Holger Bronger Journal: Mol Med Date: 2022-05-04 Impact factor: 6.376