Timothy Baird1,2, Rebecca Theal3, Sarah Gleeson1,2, Sarah McLeay5, Robyn O'Sullivan5,7,8, Sarah McLeay5, Wendy Harvey5, Madeline Romaniuk5,6, Darrell Crawford5,7,8, David Colquhoun5,7,8, Ross McD Young5,9, Miriam Dwyer5, John Gibson5,8, Robyn O'Sullivan5,7,8, Graham Cooksley5,7, Christopher Strakosch5,7,8, Rachel Thomson5,7,8, Joanne Voisey5,6, Bruce Lawford5,6,7,8. 1. Sleep Care, Greenslopes Private Hospital, Brisbane, Queensland, Australia. 2. Greenslopes Private Hospital, Brisbane, Queensland, Australia. 3. Gallipoli Medical Research Institute, Brisbane, Queensland, Australia. 4. The University of Queensland, Brisbane, Queensland, Australia. 5. Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Newdegate St, Greenslopes. 6. School of Biomedical Sciences, Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD. 7. School of Medicine, The University of Queensland, Herston, Queensland. 8. Greenslopes Private Hospital, Newdegate St, Greenslopes, Queensland. 9. Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD.
Abstract
STUDY OBJECTIVES: Recent results from the PTSD Initiative, a cross-sectional cohort study in Australian Vietnam veterans (VV) with and without posttraumatic stress disorder (PTSD), demonstrated an increased prevalence of self-reported sleep disturbances in those with PTSD. This study aimed to objectively assess the prevalence of sleep disorders in the same cohort using detailed polysomnography (PSG). METHODS: Participants from the PTSD Initiative were recruited to undergo PSG. PTSD status was determined with the Clinician Administered PTSD Scale for DSM-5 (CAPS-5). Subjective sleep information was attained via structured questionnaires. Data from single night PSG were compared between trauma-exposed VV with and without PTSD. RESULTS: A total of 74 trauma-exposed male VV (40 with PTSD) underwent PSG (prospective n = 59, retrospective n = 15). All PSG parameters were similar between groups. No difference was seen in PSG-diagnosed obstructive sleep apnea (OSA) or periodic limb movements of sleep (PLMS). VV with PTSD showed a trend toward increased duration of sleep with oxygen saturations < 90% (10% versus 1.8%; P = .07). VV with PTSD reported increased sleep onset latency (42.4 versus 13.3 minutes; P < .01); were less likely to report sleeping well (32.5% versus 67.5%; P < .01); had higher OSA risk using Berlin Questionnaire (BQ) (70% versus 38.2%; P < .01); and had higher rates of partner-reported limb movements (56.4% versus 17.6%; P < .01). No association between PSG-diagnosed OSA and PTSD severity was evident. CONCLUSIONS: In Australian VV with and without PTSD, no difference was seen across all PSG parameters including the diagnosis and severity of OSA and PLMS. However, VV with PTSD demonstrated an increased perception of sleep disturbances.
STUDY OBJECTIVES: Recent results from the PTSD Initiative, a cross-sectional cohort study in Australian Vietnam veterans (VV) with and without posttraumatic stress disorder (PTSD), demonstrated an increased prevalence of self-reported sleep disturbances in those with PTSD. This study aimed to objectively assess the prevalence of sleep disorders in the same cohort using detailed polysomnography (PSG). METHODS:Participants from the PTSD Initiative were recruited to undergo PSG. PTSD status was determined with the Clinician Administered PTSD Scale for DSM-5 (CAPS-5). Subjective sleep information was attained via structured questionnaires. Data from single night PSG were compared between trauma-exposed VV with and without PTSD. RESULTS: A total of 74 trauma-exposed male VV (40 with PTSD) underwent PSG (prospective n = 59, retrospective n = 15). All PSG parameters were similar between groups. No difference was seen in PSG-diagnosed obstructive sleep apnea (OSA) or periodic limb movements of sleep (PLMS). VV with PTSD showed a trend toward increased duration of sleep with oxygen saturations < 90% (10% versus 1.8%; P = .07). VV with PTSD reported increased sleep onset latency (42.4 versus 13.3 minutes; P < .01); were less likely to report sleeping well (32.5% versus 67.5%; P < .01); had higher OSA risk using Berlin Questionnaire (BQ) (70% versus 38.2%; P < .01); and had higher rates of partner-reported limb movements (56.4% versus 17.6%; P < .01). No association between PSG-diagnosed OSA and PTSD severity was evident. CONCLUSIONS: In Australian VV with and without PTSD, no difference was seen across all PSG parameters including the diagnosis and severity of OSA and PLMS. However, VV with PTSD demonstrated an increased perception of sleep disturbances.
Authors: Sarah C McLeay; Wendy M Harvey; Madeline Nm Romaniuk; Darrell Hg Crawford; David M Colquhoun; Ross McD Young; Miriam Dwyer; John M Gibson; Robyn A O'Sullivan; Graham Cooksley; Christopher R Strakosch; Rachel M Thomson; Joanne Voisey; Bruce R Lawford Journal: Med J Aust Date: 2017-04-03 Impact factor: 7.738
Authors: T C Neylan; C R Marmar; T J Metzler; D S Weiss; D F Zatzick; K L Delucchi; R M Wu; F B Schoenfeld Journal: Am J Psychiatry Date: 1998-07 Impact factor: 18.112