Hao Sun1, Qingsong Li2, Yingji Jin1, Hongmei Qiao3. 1. Department of Paediatrics, Taizhou People's Hospital, Taizhou, China. 2. Department of Orthopedics, Taizhou People's Hospital, Taizhou, China. 3. Department of Paediatrics, First Hospital of Jilin University, Changchun, China. Electronic address: hongmeiqiao99869@163.com.
Abstract
OBJECTIVE: Recently, potential correlations between tumor necrosis factor-α (TNF-α) polymorphisms and asthma were investigated by some pilot studies, but the results of these studies were inconsistent. Therefore, we performed this meta-analysis to better evaluate the relationship between TNF-α polymorphisms and the risk of asthma. METHODS: Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess correlations between TNF-α polymorphisms and asthma. RESULTS: A total of 50 studies were included for analyses. Significant associations with the risk of asthma were detected for TNF-α - 238 G/A, -308 G/A and - 857C/T polymorphisms in overall analyses. Further subgroup analyses according to ethnicity of participants revealed that TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians, TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians, and TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians. CONCLUSIONS: Our findings indicated that TNF-α - 238 G/A, -308 G/A, -857C/T, -863C/A and - 1031 T/C polymorphisms may serve as potential biological markers for asthma in certain ethnicities.
OBJECTIVE: Recently, potential correlations between tumor necrosis factor-α (TNF-α) polymorphisms and asthma were investigated by some pilot studies, but the results of these studies were inconsistent. Therefore, we performed this meta-analysis to better evaluate the relationship between TNF-α polymorphisms and the risk of asthma. METHODS: Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess correlations between TNF-α polymorphisms and asthma. RESULTS: A total of 50 studies were included for analyses. Significant associations with the risk of asthma were detected for TNF-α - 238 G/A, -308 G/A and - 857C/T polymorphisms in overall analyses. Further subgroup analyses according to ethnicity of participants revealed that TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians, TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians, and TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians. CONCLUSIONS: Our findings indicated that TNF-α - 238 G/A, -308 G/A, -857C/T, -863C/A and - 1031 T/C polymorphisms may serve as potential biological markers for asthma in certain ethnicities.
Authors: Anna Woziwodzka; Magda Rybicka; Alicja Sznarkowska; Tomasz Romanowski; Marcin Dręczewski; Piotr Stalke; Krzysztof Piotr Bielawski Journal: Mol Genet Genomic Med Date: 2019-08-23 Impact factor: 2.183