Yanzhen Xu1,2, Nanfang Mo2, Zhiwen Jiang2, Shaoming Lu3, Shien Fu2, Xinyan Wei2, Dong Zhao2, Zhibin Xie2,3,4, Wenxian Jia2,5, Jiayi Liu2, Xiao Wang2, Dongchen Shi6, Yang Jiao4, Chengwu Liu1, Xiaoli Yang2. 1. Department of Pathophysiology, Guangxi Medical University, Nanning, Guangxi, China. 2. Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China. 3. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. 4. Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. 5. College of Pharmacy, Guangxi Medical University, Nanning, Guangxi, China. 6. School of environmental science and engineering, Sun Yat-sen University, Guangzhou, China.
Abstract
Objectives: Human leukocyteantigen (HLA) is the most important gene for immune system regulation. Although studies have evaluated the association between HLA-DRB1 allele polymorphisms and systemic sclerosis (SSc), their results are still controversial. We performed a meta-analysis to assess the association of HLA-DRB1 alleles with risk of SSc. Methods: Electronic database were systematically searched for articles, a total of 11 case-control studies including 3268 cases and 5548 controls were analyzed. Odds ratio (ORs) and 95% confidence intervals were used to assess the association of HLA-DRB1 alleles with SSc. The relationship between SSc-related autoantibodies and DRB1 alleles was also analyzed. Results: In the overall analysis, four alleles (DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04) increased the risk of SSc; however, five alleles (DRB1*07, DRB1*11:01, DRB1*13, DRB1*13:01, and DRB1*14) had the opposite effect. Analysis of subgroups by ethnicity indicate that DRB1*11:01 and DRB1*13:01 confer a protective effect in Caucasians, while DRB1*11:04 was associated with a higher risk of SSc. For Asian, DRB1*13:02 was found to be a protective factor. In addition, the frequency of DRB1*11:04 alleles was significantly increased in ATA+ SSc patients compared with ATA- SSc patients. Conclusion: DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04 were associated with the risk of SSc. Additionally, DRB1*11 and DRB1*11:04 were association with ATAs.
Objectives:Human leukocyteantigen (HLA) is the most important gene for immune system regulation. Although studies have evaluated the association between HLA-DRB1 allele polymorphisms and systemic sclerosis (SSc), their results are still controversial. We performed a meta-analysis to assess the association of HLA-DRB1 alleles with risk of SSc. Methods: Electronic database were systematically searched for articles, a total of 11 case-control studies including 3268 cases and 5548 controls were analyzed. Odds ratio (ORs) and 95% confidence intervals were used to assess the association of HLA-DRB1 alleles with SSc. The relationship between SSc-related autoantibodies and DRB1 alleles was also analyzed. Results: In the overall analysis, four alleles (DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04) increased the risk of SSc; however, five alleles (DRB1*07, DRB1*11:01, DRB1*13, DRB1*13:01, and DRB1*14) had the opposite effect. Analysis of subgroups by ethnicity indicate that DRB1*11:01 and DRB1*13:01 confer a protective effect in Caucasians, while DRB1*11:04 was associated with a higher risk of SSc. For Asian, DRB1*13:02 was found to be a protective factor. In addition, the frequency of DRB1*11:04 alleles was significantly increased in ATA+ SSc patients compared with ATA- SSc patients. Conclusion:DRB1*04:03, DRB1*08, DRB1*11, and DRB1*11:04 were associated with the risk of SSc. Additionally, DRB1*11 and DRB1*11:04 were association with ATAs.
Authors: Vincent van Drongelen; Bruna Miglioranza Scavuzzi; Sarah Veloso Nogueira; Frederick W Miller; Amr H Sawalha; Joseph Holoshitz Journal: Sci Rep Date: 2021-01-28 Impact factor: 4.379