Polymerization-Induced Self-Assembly under Compressed CO2 : Control of Morphology Using a CO2 -Responsive MacroRAFT Agent.

Polymerization-induced self-assembly of 2-hydroxypropyl methacrylate is conducted in water and water/MeOH using a CO2 -responsive macroRAFT agent in the form of a statistical copolymer comprising N,N-diethylaminoethyl methacrylate (DEAEMA) and poly(ethylene glycol) methyl ether methacrylate (M n  = 475 g mol-1 ). Pressurization with CO2 leads to protonation of DEAEMA units within the stabilizer block, thereby offering a means of adjusting the charge density of the coronal layer. It is demonstrated that a wide range of tunable particle morphologies are accessible by simply varying the CO2 pressure during polymerization in the range of 10-45 bar.