| Literature DB >> 30174134 |
Lu Qiao1, Yajun Yang2, Pengcheng Fu3, Sile Hu1, Hang Zhou1, Shouneng Peng1, Jingze Tan2, Yan Lu1, Haiyi Lou1, Dongsheng Lu1, Sijie Wu1, Jing Guo1, Li Jin4, Yaqun Guan5, Sijia Wang6, Shuhua Xu7, Kun Tang8.
Abstract
It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies (GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.Entities:
Keywords: Ancestry-divergent phenotypes; Dense 3D facial image; Face prediction; Forensic scenario; Genome-wide association study
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Year: 2018 PMID： 30174134 DOI： 10.1016/j.jgg.2018.07.009
Source DB: PubMed Journal: J Genet Genomics ISSN： 1673-8527 Impact factor: 4.275