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Literature DB >> 30173293

Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities.

Wenwen Peng^1,2,3, Guanghu Huo⁴, Lixia Zheng⁵, Zhonghua Xiong⁵, Xugen Shi⁵, Dayong Peng⁶.

Abstract

Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3-5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.

Entities: Chemical Disease

Keywords: A549; Cytotoxic activities; HeLa; Leonurus japonicus; Oleanane triterpenes

Mesh：

Substances：

Year: 2018 PMID： 30173293 DOI： 10.1007/s11418-018-1244-4

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

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References

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Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities.

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