L Plans1, C Barrot2, E Nieto1, J Rios3, T G Schulze4, S Papiol5, M Mitjans6, E Vieta7, A Benabarre8. 1. Mental Health Division of Althaia, Xarxa Assistencial Universitària de Manresa, Catalonia, Spain. 2. Forensic Genetic Laboratori, University of Barcelona, Catalonia, Spain. 3. Universitat Autònoma de Barcelona, Laboratório de Bioestatística e Epidemiologia, Barcelona, Spain; Hospital Clínic, IDIBAPS, Bioestadística y Plataforma de Gestión de Datos, Barcelona, Spain. 4. Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University, Munich, Germany. 5. Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University, Munich, Germany; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich, Germany. 6. Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany. 7. Bipolar Disorder Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address: evieta@clinic.ub.es. 8. Bipolar Disorder Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Abstract
BACKGROUND: Completed suicide is a major cause of death in bipolar disorder (BD) patients. OBJECTIVE: The aim of this paper is to provide an overall review of the existing literature of completed suicide in BD patients, including clinical and genetic data DATA SOURCES: We performed a systematic review of English and non-English articles published on MEDLINE/PubMed, PsycInfo and Cochrane database (1970-2017). Additional studies were identified by contacting clinical experts, searching bibliographies, major textbooks and website of World Health Organization. Initially we did a broad search for the association of bipolar disorder and suicide and we were narrowing the search in terms included "bipolar disorder" and "completed suicide". STUDY SELECTION: Inclusion criteria were articles about completed suicide in patients with BD. Articles exclusively focusing on suicide attempts and suicidal behaviour have been excluded. We used PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) consensus for drafting this systematic review. RESULTS: The initial search generated 2806 articles and a total of 61 meeting our inclusion criteria. We reviewed epidemiological data, genetic factors, risk factors and treatment of completed suicide in BD. Suicide rates in BD vary between studies but our analyses show that they are approximately 20-30-fold greater than in general population. The highest risk of successful suicide was observed in BD-II subjects. The heritability of completed suicide is about 40% and some genes related to major neurotransmitter systems have been associated with suicide. Lithium is the only treatment that has shown anti-suicide potential. LIMITATIONS: The most important limitation of the present review is the limited existing literature on completed suicide in BD. CONCLUSIONS: BD patients are at high risk for suicide. It is possible to identify some factors related to completed suicide, such as early onset, family history of suicide among first-degree relatives, previous attempted suicides, comorbidities and treatment. However it is necessary to promote research on this serious health problem.
BACKGROUND: Completed suicide is a major cause of death in bipolar disorder (BD) patients. OBJECTIVE: The aim of this paper is to provide an overall review of the existing literature of completed suicide in BD patients, including clinical and genetic data DATA SOURCES: We performed a systematic review of English and non-English articles published on MEDLINE/PubMed, PsycInfo and Cochrane database (1970-2017). Additional studies were identified by contacting clinical experts, searching bibliographies, major textbooks and website of World Health Organization. Initially we did a broad search for the association of bipolar disorder and suicide and we were narrowing the search in terms included "bipolar disorder" and "completed suicide". STUDY SELECTION: Inclusion criteria were articles about completed suicide in patients with BD. Articles exclusively focusing on suicide attempts and suicidal behaviour have been excluded. We used PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) consensus for drafting this systematic review. RESULTS: The initial search generated 2806 articles and a total of 61 meeting our inclusion criteria. We reviewed epidemiological data, genetic factors, risk factors and treatment of completed suicide in BD. Suicide rates in BD vary between studies but our analyses show that they are approximately 20-30-fold greater than in general population. The highest risk of successful suicide was observed in BD-II subjects. The heritability of completed suicide is about 40% and some genes related to major neurotransmitter systems have been associated with suicide. Lithium is the only treatment that has shown anti-suicide potential. LIMITATIONS: The most important limitation of the present review is the limited existing literature on completed suicide in BD. CONCLUSIONS: BD patients are at high risk for suicide. It is possible to identify some factors related to completed suicide, such as early onset, family history of suicide among first-degree relatives, previous attempted suicides, comorbidities and treatment. However it is necessary to promote research on this serious health problem.
Authors: Giovanna Punzi; Gianluca Ursini; Qiang Chen; Eugenia Radulescu; Ran Tao; Louise A Huuki; Pasquale Di Carlo; Leonardo Collado-Torres; Joo Heon Shin; Roberto Catanesi; Andrew E Jaffe; Thomas M Hyde; Joel E Kleinman; Trudy F C Mackay; Daniel R Weinberger Journal: Am J Psychiatry Date: 2022-03 Impact factor: 18.112
Authors: Niamh Mullins; Andreas J Forstner; Kevin S O'Connell; Brandon Coombes; Jonathan R I Coleman; Zhen Qiao; Thomas D Als; Tim B Bigdeli; Sigrid Børte; Julien Bryois; Alexander W Charney; Ole Kristian Drange; Michael J Gandal; Saskia P Hagenaars; Masashi Ikeda; Nolan Kamitaki; Minsoo Kim; Kristi Krebs; Georgia Panagiotaropoulou; Brian M Schilder; Laura G Sloofman; Stacy Steinberg; Vassily Trubetskoy; Bendik S Winsvold; Hong-Hee Won; Liliya Abramova; Kristina Adorjan; Esben Agerbo; Mariam Al Eissa; Diego Albani; Ney Alliey-Rodriguez; Adebayo Anjorin; Verneri Antilla; Anastasia Antoniou; Swapnil Awasthi; Ji Hyun Baek; Marie Bækvad-Hansen; Nicholas Bass; Michael Bauer; Eva C Beins; Sarah E Bergen; Armin Birner; Carsten Bøcker Pedersen; Erlend Bøen; Marco P Boks; Rosa Bosch; Murielle Brum; Ben M Brumpton; Nathalie Brunkhorst-Kanaan; Monika Budde; Jonas Bybjerg-Grauholm; William Byerley; Murray Cairns; Miquel Casas; Pablo Cervantes; Toni-Kim Clarke; Cristiana Cruceanu; Alfredo Cuellar-Barboza; Julie Cunningham; David Curtis; Piotr M Czerski; Anders M Dale; Nina Dalkner; Friederike S David; Franziska Degenhardt; Srdjan Djurovic; Amanda L Dobbyn; Athanassios Douzenis; Torbjørn Elvsåshagen; Valentina Escott-Price; I Nicol Ferrier; Alessia Fiorentino; Tatiana M Foroud; Liz Forty; Josef Frank; Oleksandr Frei; Nelson B Freimer; Louise Frisén; Katrin Gade; Julie Garnham; Joel Gelernter; Marianne Giørtz Pedersen; Ian R Gizer; Scott D Gordon; Katherine Gordon-Smith; Tiffany A Greenwood; Jakob Grove; José Guzman-Parra; Kyooseob Ha; Magnus Haraldsson; Martin Hautzinger; Urs Heilbronner; Dennis Hellgren; Stefan Herms; Per Hoffmann; Peter A Holmans; Laura Huckins; Stéphane Jamain; Jessica S Johnson; Janos L Kalman; Yoichiro Kamatani; James L Kennedy; Sarah Kittel-Schneider; James A Knowles; Manolis Kogevinas; Maria Koromina; Thorsten M Kranz; Henry R Kranzler; Michiaki Kubo; Ralph Kupka; Steven A Kushner; Catharina Lavebratt; Jacob Lawrence; Markus Leber; Heon-Jeong Lee; Phil H Lee; Shawn E Levy; 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Beata Świątkowska; Chikashi Terao; Thorgeir E Thorgeirsson; Claudio Toma; Paul Tooney; Evangelia-Eirini Tsermpini; Marquis P Vawter; Helmut Vedder; James T R Walters; Stephanie H Witt; Simon Xi; Wei Xu; Jessica Mei Kay Yang; Allan H Young; Hannah Young; Peter P Zandi; Hang Zhou; Lea Zillich; Rolf Adolfsson; Ingrid Agartz; Martin Alda; Lars Alfredsson; Gulja Babadjanova; Lena Backlund; Bernhard T Baune; Frank Bellivier; Susanne Bengesser; Wade H Berrettini; Douglas H R Blackwood; Michael Boehnke; Anders D Børglum; Gerome Breen; Vaughan J Carr; Stanley Catts; Aiden Corvin; Nicholas Craddock; Udo Dannlowski; Dimitris Dikeos; Tõnu Esko; Bruno Etain; Panagiotis Ferentinos; Mark Frye; Janice M Fullerton; Micha Gawlik; Elliot S Gershon; Fernando S Goes; Melissa J Green; Maria Grigoroiu-Serbanescu; Joanna Hauser; Frans Henskens; Jan Hillert; Kyung Sue Hong; David M Hougaard; Christina M Hultman; Kristian Hveem; Nakao Iwata; Assen V Jablensky; Ian Jones; Lisa A Jones; René S Kahn; John R Kelsoe; 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Eystein Stordal; Fabian Streit; Patrick F Sullivan; Gustavo Turecki; Arne E Vaaler; Eduard Vieta; John B Vincent; Irwin D Waldman; Thomas W Weickert; Thomas Werge; Naomi R Wray; John-Anker Zwart; Joanna M Biernacka; John I Nurnberger; Sven Cichon; Howard J Edenberg; Eli A Stahl; Andrew McQuillin; Arianna Di Florio; Roel A Ophoff; Ole A Andreassen Journal: Nat Genet Date: 2021-05-17 Impact factor: 38.330
Authors: João Paulo Lima Santos; David Brent; Michele Bertocci; Sarrah Mailliard; Genna Bebko; Tina Goldstein; Tae Kim; Satish Iyengar; Danella Hafeman; Vilde Chaya Fenster-Ehrlich; Alexander Skeba; Lisa Bonar; Halimah Abdul-Waalee; MaryKay Gill; John Merranko; Boris Birmaher; Mary L Phillips; Amelia Versace Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2020-07-18