T McAlindon1, M Roberts2, J Driban3, L Schaefer4, I K Haugen5, S E Smith6, J Duryea7, D Cunha8, F Blanco9, J-L Fernández-Garcia10, C Eaton11. 1. Division of Rheumatology, Tufts Medical Center, Boston, MA, USA. Electronic address: tmcalindon@tuftsmedicalcenter.org. 2. Center for Primary Care & Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA. Electronic address: mroberts@carene.org. 3. Division of Rheumatology, Tufts Medical Center, Boston, MA, USA. Electronic address: jdriban@tuftsmedicalcenter.org. 4. Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: lenafranziskaschaefer@yahoo.com. 5. Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. Electronic address: ida.k.haugen@gmail.com. 6. Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: ssmith@bwh.harvard.edu. 7. Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: jduryea@bwh.harvard.edu. 8. Division of Rheumatology, Tufts Medical Center, Boston, MA, USA. Electronic address: dcunha3@tuftsmedicalcenter.org. 9. INIBIC - Complexo Hospitalario Universitario A Coruña, Rheumatology Division, As Xubias 84, 15006, A Coruña, Spain. Electronic address: fblagar@sergas.es. 10. INIBIC - Complexo Hospitalario Universitario A Coruña, Genetics Unit, As Xubias 84, 15006, A Coruña, Spain. Electronic address: jose.luis.fernandez.garcia@sergas.es. 11. Center for Primary Care & Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA. Electronic address: cbeaton51@gmail.com.
Abstract
OBJECTIVE: To evaluate the relationship of telomere length to the prevalence and incidence of hand osteoarthritis in a longitudinal cohort. DESIGN: We conducted a cross-sectional and longitudinal analysis of data from a subset of participants in the Osteoarthritis Initiative (OAI) recruited between February 2004 and May 2006. 274 individuals were eligible for the study based on availability of both baseline and 48-month hand radiographs and peripheral blood leucocyte telomere length data. Mean telomere length of peripheral blood leukocytes (PBL)s from the DNA samples was determined using a validated quantitative polymerase chain reaction (PCR)-based assay, and hand radiographs were analyzed and graded using the Kellgren-Lawrence scale. RESULTS: In joint -level analyses, prevalent Interphalangeal Joint Osteoarthritis (IPJOA) was significantly associated with PBL telomere length in the baseline sample in unadjusted analyses (RR = 2.84; 95% CI:0.87-9.29) or in models adjusted for age, sex, and body mass index (aRR = 1.10; 95% CI: 0.96-1.27). The association in crude and adjusted analyses appeared slightly stronger with incident IPJOA, especially in the subset with normal hands at baseline (aRR = 1.62; 95% CI: 1.02-2.57). PBL telomere length was also associated with prevalent HOA at baseline (significant in unadjusted analysis: RR = 1.22; 95% CI 1.06-1.42), but not after adjusting for covariates: aRR = 1.12; 95% CI: 0.96-1.30). The magnitude of association was stronger for incident HOA, especially incident symptomatic HOA (aRR = 1.53; 95% CI: 1.09-2.15). CONCLUSIONS: In summary, the results of this exploratory analysis are confirmatory of previous work showing a cross-sectional relationship between telomere length and HOA and add to the field by demonstrating an even stronger association with incident IPJOA, both radiographic and symptomatic.
OBJECTIVE: To evaluate the relationship of telomere length to the prevalence and incidence of hand osteoarthritis in a longitudinal cohort. DESIGN: We conducted a cross-sectional and longitudinal analysis of data from a subset of participants in the Osteoarthritis Initiative (OAI) recruited between February 2004 and May 2006. 274 individuals were eligible for the study based on availability of both baseline and 48-month hand radiographs and peripheral blood leucocyte telomere length data. Mean telomere length of peripheral blood leukocytes (PBL)s from the DNA samples was determined using a validated quantitative polymerase chain reaction (PCR)-based assay, and hand radiographs were analyzed and graded using the Kellgren-Lawrence scale. RESULTS: In joint -level analyses, prevalent Interphalangeal Joint Osteoarthritis (IPJOA) was significantly associated with PBL telomere length in the baseline sample in unadjusted analyses (RR = 2.84; 95% CI:0.87-9.29) or in models adjusted for age, sex, and body mass index (aRR = 1.10; 95% CI: 0.96-1.27). The association in crude and adjusted analyses appeared slightly stronger with incident IPJOA, especially in the subset with normal hands at baseline (aRR = 1.62; 95% CI: 1.02-2.57). PBL telomere length was also associated with prevalent HOA at baseline (significant in unadjusted analysis: RR = 1.22; 95% CI 1.06-1.42), but not after adjusting for covariates: aRR = 1.12; 95% CI: 0.96-1.30). The magnitude of association was stronger for incident HOA, especially incident symptomatic HOA (aRR = 1.53; 95% CI: 1.09-2.15). CONCLUSIONS: In summary, the results of this exploratory analysis are confirmatory of previous work showing a cross-sectional relationship between telomere length and HOA and add to the field by demonstrating an even stronger association with incident IPJOA, both radiographic and symptomatic.
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