Colien Hazelaar1, Lineke van der Weide2, Hassan Mostafavi3, Ben J Slotman4, Wilko F A R Verbakel5, Max Dahele6. 1. Department of Radiation Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: c.hazelaar@vumc.nl. 2. Department of Radiation Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: l.vanderweide@vumc.nl. 3. Varian Medical Systems, Palo Alto, CA, USA. Electronic address: hassan.mostafavi@varian.com. 4. Department of Radiation Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: bj.slotman@vumc.nl. 5. Department of Radiation Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: w.verbakel@vumc.nl. 6. Department of Radiation Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: m.dahele@vumc.nl.
Abstract
BACKGROUND AND PURPOSE: Central lung stereotactic body radiotherapy (SBRT) can cause proximal bronchial tree (PBT) toxicity. Information on PBT position relative to the high-dose could aid risk management. We investigated template matching + triangulation for high-frequency markerless 3D PBT position monitoring. MATERIALS AND METHODS: Kilovoltage projections of a moving phantom (full-fan cone-beam CT [CBCT, 15 frames/second] without MV irradiation: 889 images/dataset + CBCT and 7 frames/second fluoroscopy with MV irradiation) and ten patients undergoing free-breathing stereotactic/hypofractionated lung irradiation (full-fan CBCT without MV irradiation, 470-500 images/dataset) were retrospectively analyzed. 2D PBT reference templates (1 filtered digitally reconstructed radiograph/°) were created from planning CT data. Using normalized cross-correlation, templates were matched to projection images for 2D position. Multiple registrations were triangulated for 3D position. RESULTS: For the phantom, 2D right/left PBT position could be determined in 86.6/75.1% of the CBCT dataset without MV irradiation, and 3D position (excluding first 20° due to the minimum triangulation angle) in 84.7/72.7%. With MV irradiation, this was up to 2% less. For right/left PBT, root-mean-square errors of measured versus "known" position were 0.5/0.8, 0.4-0.5/0.7, and 0.4/0.5-0.6 mm for left-right, superior-inferior, and anterior-posterior directions, respectively. 2D PBT position was determined in, on average, 89.8% of each patient dataset (range: 79.4-99.2%), and 3D position (excluding first 20°) in 85.1% (range: 67.9-99.6%). Motion was mainly superior-inferior (range: 4.5-13.6 mm, average: 8.5 mm). CONCLUSIONS: High-frequency 3D PBT position verification during free-breathing is technically feasible using markerless template matching + triangulation of kilovoltage projection images acquired during gantry rotation. Applications include organ-at-risk position monitoring during central lung SBRT.
BACKGROUND AND PURPOSE: Central lung stereotactic body radiotherapy (SBRT) can cause proximal bronchial tree (PBT) toxicity. Information on PBT position relative to the high-dose could aid risk management. We investigated template matching + triangulation for high-frequency markerless 3D PBT position monitoring. MATERIALS AND METHODS: Kilovoltage projections of a moving phantom (full-fan cone-beam CT [CBCT, 15 frames/second] without MV irradiation: 889 images/dataset + CBCT and 7 frames/second fluoroscopy with MV irradiation) and ten patients undergoing free-breathing stereotactic/hypofractionated lung irradiation (full-fan CBCT without MV irradiation, 470-500 images/dataset) were retrospectively analyzed. 2D PBT reference templates (1 filtered digitally reconstructed radiograph/°) were created from planning CT data. Using normalized cross-correlation, templates were matched to projection images for 2D position. Multiple registrations were triangulated for 3D position. RESULTS: For the phantom, 2D right/left PBT position could be determined in 86.6/75.1% of the CBCT dataset without MV irradiation, and 3D position (excluding first 20° due to the minimum triangulation angle) in 84.7/72.7%. With MV irradiation, this was up to 2% less. For right/left PBT, root-mean-square errors of measured versus "known" position were 0.5/0.8, 0.4-0.5/0.7, and 0.4/0.5-0.6 mm for left-right, superior-inferior, and anterior-posterior directions, respectively. 2D PBT position was determined in, on average, 89.8% of each patient dataset (range: 79.4-99.2%), and 3D position (excluding first 20°) in 85.1% (range: 67.9-99.6%). Motion was mainly superior-inferior (range: 4.5-13.6 mm, average: 8.5 mm). CONCLUSIONS: High-frequency 3D PBT position verification during free-breathing is technically feasible using markerless template matching + triangulation of kilovoltage projection images acquired during gantry rotation. Applications include organ-at-risk position monitoring during central lung SBRT.
Authors: Wei Zhao; Bin Han; Yong Yang; Mark Buyyounouski; Steven L Hancock; Hilary Bagshaw; Lei Xing Journal: Radiother Oncol Date: 2019-07-11 Impact factor: 6.280
Authors: Marco Mueller; Per Poulsen; Rune Hansen; Wilko Verbakel; Ross Berbeco; Dianne Ferguson; Shinichiro Mori; Lei Ren; John C Roeske; Lei Wang; Pengpeng Zhang; Paul Keall Journal: Med Phys Date: 2021-12-29 Impact factor: 4.071