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Literature DB >> 301709

Retinal enzyme activities under hypoxic conditions prior to neovascularization.

Abstract

In an effort to demonstrate biochemical changes occuring in malperfused retinas, oxygen-induced retrolental fibroplasia was produced in kittens. Immediately before the onset of vasoproliferations, that is in the stage of maximal hypoxia, the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), malate dehydrogenase (MDH) and isocitrate dehydrogenase (ICDH) were determined. The activity of MDH was found to be significantly decreased, whereas the activities of the other enzymes showed no major changes.

Entities: Chemical Disease Gene

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Year: 1977 PMID： 301709 DOI： 10.1007/bf00410996

Source DB: PubMed Journal: Albrecht Von Graefes Arch Klin Exp Ophthalmol ISSN： 0065-6100

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References

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Retinal enzyme activities under hypoxic conditions prior to neovascularization.

1. FLUORESCEIN STUDIES OF DIABETIC RETINOPATHY.

2. Effects of prolonged light deprivation on the development of retinal enzymes in the rabbit.

3. [The glycolytic erzyme pattern in the liver, kidney, skeletal muscle, heart muscle and brain of rats and mice].

4. Neovascularization in ocular disease.

5. Lactate metabolism.

6. Regulation of thiols in the brain. 2. Effect of hypoxia on the activities of cytoplasmic NADPH-producing enzymes in different parts of the rat brain.

7. Retinal neovascularization, collaterals, and vascular shunts.

8. The role of lactic acid in retinal neovascularization.

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10. Effects of ischaemia on metabolite concentrations in rat liver.