Rachel L Epstein1, Vishakha Sabharwal2, Elisha M Wachman3, Kelley A Saia4, Claudia Vellozzi5, Susan Hariri5, Benjamin P Linas6. 1. Department of Pediatrics, Section of Infectious Diseases, Boston Medical Center, Boston, MA; Department of Internal Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA. Electronic address: rachel.epstein@bmc.org. 2. Department of Pediatrics, Section of Infectious Diseases, Boston Medical Center, Boston, MA. 3. Department of Pediatrics, Division of Neonatology, Boston Medical Center, Boston, MA. 4. Department of Obstetrics and Gynecology, Boston Medical Center, Boston, MA. 5. Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA. 6. Department of Internal Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA.
Abstract
OBJECTIVES: The US National Viral Hepatitis Action Plan calls for major efforts to expand hepatitis C virus (HCV) diagnosis and treatment; prenatal care settings are potential venues for expanding HCV testing. We aimed to characterize the HCV diagnostic cascade for women and infants and investigate factors associated with linkage and follow-up. STUDY DESIGN: We used electronic health records for a 10-year cohort of 879 women with opioid use disorder from an obstetric clinic serving women with substance use disorders. RESULTS: Altogether, 744 women (85%) were screened for HCV; 510 (68%) were seropositive, of whom 369 (72%) had nucleic acid testing performed and of these 261 (71%) were viremic. Of 404 infants born to HCV-seropositive women, 273 (68%) were tested at least once for HCV, 180 (45%) completed the American Academy of Pediatrics-recommended perinatal HCV screening, and 5 (2.8%) were diagnosed with HCV infection and linked to care. More recent delivery date (2014-2015) was associated with maternal linkage to care (aOR, 2.5; 95% CI, 1.4-4.7). Maternal coinfection with HIV (aOR, 9.0; 95% CI, 1.1-72.8) and methadone maintenance therapy, compared with buprenorphine (aOR, 1.5; 95% CI, 0.9-2.5), were associated with higher rates of infant HCV testing. CONCLUSIONS: HCV prevalence among pregnant women with opioid use is high and infant HCV screening is imperfect. Programmatic changes to improve both mother and infant follow-up may help to bridge identified gaps in the cascade to cure.
OBJECTIVES: The US National Viral Hepatitis Action Plan calls for major efforts to expand hepatitis C virus (HCV) diagnosis and treatment; prenatal care settings are potential venues for expanding HCV testing. We aimed to characterize the HCV diagnostic cascade for women and infants and investigate factors associated with linkage and follow-up. STUDY DESIGN: We used electronic health records for a 10-year cohort of 879 women with opioid use disorder from an obstetric clinic serving women with substance use disorders. RESULTS: Altogether, 744 women (85%) were screened for HCV; 510 (68%) were seropositive, of whom 369 (72%) had nucleic acid testing performed and of these 261 (71%) were viremic. Of 404 infants born to HCV-seropositive women, 273 (68%) were tested at least once for HCV, 180 (45%) completed the American Academy of Pediatrics-recommended perinatal HCV screening, and 5 (2.8%) were diagnosed with HCV infection and linked to care. More recent delivery date (2014-2015) was associated with maternal linkage to care (aOR, 2.5; 95% CI, 1.4-4.7). Maternal coinfection with HIV (aOR, 9.0; 95% CI, 1.1-72.8) and methadone maintenance therapy, compared with buprenorphine (aOR, 1.5; 95% CI, 0.9-2.5), were associated with higher rates of infant HCV testing. CONCLUSIONS: HCV prevalence among pregnant women with opioid use is high and infant HCV screening is imperfect. Programmatic changes to improve both mother and infant follow-up may help to bridge identified gaps in the cascade to cure.
Authors: Mary V Greiner; Sarah J Beal; Katie Nause; Mary Allen Staat; Judith W Dexheimer; Philip V Scribano Journal: Pediatrics Date: 2017-11-15 Impact factor: 7.124
Authors: Aymin Delgado-Borrego; Lesley Smith; Maureen M Jonas; Cyndena A Hall; Betania Negre; Sergio H Jordan; Matthew Ogrodowicz; Roshan Raza; David A Ludwig; Tracie Miller; Steven E Lipshultz; Regino Gonzalez-Peralta; Raymond T Chung Journal: J Pediatr Date: 2012-07-03 Impact factor: 4.406
Authors: Cara L Mack; Regino P Gonzalez-Peralta; Nitika Gupta; Daniel Leung; Michael R Narkewicz; Eve A Roberts; Philip Rosenthal; Kathleen B Schwarz Journal: J Pediatr Gastroenterol Nutr Date: 2012-06 Impact factor: 2.839
Authors: Catherine A Chappell; Sharon L Hillier; David Crowe; Leslie A Meyn; Debra L Bogen; Elizabeth E Krans Journal: Pediatrics Date: 2018-05-02 Impact factor: 7.124
Authors: Benjamin P Linas; Devra M Barter; Jared A Leff; Sabrina A Assoumou; Joshua A Salomon; Milton C Weinstein; Arthur Y Kim; Bruce R Schackman Journal: PLoS One Date: 2014-05-19 Impact factor: 3.752
Authors: Karli R Hochstatter; Lauren J Stockman; Ryan Holzmacher; James Greer; David W Seal; Quinton A Taylor; Emma K Gill; Ryan P Westergaard Journal: Health Justice Date: 2017-10-30
Authors: Susan M Lopata; Elizabeth McNeer; Judith A Dudley; Carolyn Wester; William O Cooper; James G Carlucci; Claudia M Espinosa; William Dupont; Stephen W Patrick Journal: Pediatrics Date: 2020-02-14 Impact factor: 7.124
Authors: Stella Protopapas; Liza Bronner Murrison; Scott L Wexelblatt; Jason T Blackard; Eric S Hall Journal: Open Forum Infect Dis Date: 2019-10-21 Impact factor: 3.835
Authors: Ângelo Zambam de Mattos; Jose D Debes; Andre Boonstra; Ju-Dong Yang; Domingo C Balderramo; Giovana D P Sartori; Angelo Alves de Mattos Journal: World J Gastroenterol Date: 2021-06-28 Impact factor: 5.742