Niovi Papalexopoulou1, Theodore G Dassios2, Alan Lunt3, Fiona Bartlett4, Felicity Perrin5, Cara J Bossley6, Hilary A Wyatt7, Anne Greenough8. 1. MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom; Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom. Electronic address: niovi.papalexopoulou@gmail.com. 2. Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom; Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: theodore.dassios@kcl.ac.uk. 3. MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom; Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom. Electronic address: alan.lunt@nhs.net. 4. Paediatric Dietetic Department, King's College Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: Fiona.bartlett@nhs.net. 5. Respiratory Medicine and Adult Cystic Fibrosis Service, King's College Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: felicity.perrin@nhs.net. 6. Paediatric Respiratory Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: cara.bossley@nhs.net. 7. Paediatric Cystic Fibrosis, King's College Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: hilarycarroll@live.co.uk. 8. MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom; Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom; NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, United Kingdom. Electronic address: anne.greenough@kcl.ac.uk.
Abstract
BACKGROUND: Nutrition is closely related to mortality and pulmonary and respiratory muscle function in cystic fibrosis (CF) patients. We initially validated results from a bioelectrical impedance device against dual energy x-ray absorptiometry (DEXA). We then determined whether fat free mass assessed by a portable impedance device rather than body mass index (BMI) better correlated with pulmonary function, respiratory muscle strength and exercise capacity in CF patients. METHODS: Eighteen young people and adults (median age 19, range 12-39 years) with CF had dual energy X-ray absorptiometry and direct segmental multi-frequency impedance analysis. Body composition, pulmonary function, respiratory muscle function and exercise tolerance using the impedance device were measured in 29 young people with CF with median age 15 (range 12-19) years. MAIN FINDINGS: There was a significant correlation between impedance and absorptiometry results (r2 = 0.947). Fat free mass correlated with the forced vital capacity z-score (r = 0.442, p = 0.016), maximal inspiratory pressure (r = 0.451, p = 0.014) and exercise tolerance (r = 0. 707, p < 0.001). BMI z-scores did not significantly correlate with pulmonary or respiratory muscle function. Subjects with a fat free mass z-score of ≤2 had a lower forced expiratory volume in 1 s z-score (p = 0.007), lower forced vital capacity z-score (p = 0.001), higher residual volume z-score (p = 0.042), lower maximal inspiratory pressure (p = 0.039), more days of intravenous antibiotics per year (p = 0.016) and a higher rate of chronic infections (p = 0.006). PRINCIPAL CONCLUSIONS: Fat-free mass measured by impedance correlated better with pulmonary and respiratory muscle function and exercise capacity than BMI.
BACKGROUND: Nutrition is closely related to mortality and pulmonary and respiratory muscle function in cystic fibrosis (CF) patients. We initially validated results from a bioelectrical impedance device against dual energy x-ray absorptiometry (DEXA). We then determined whether fat free mass assessed by a portable impedance device rather than body mass index (BMI) better correlated with pulmonary function, respiratory muscle strength and exercise capacity in CF patients. METHODS: Eighteen young people and adults (median age 19, range 12-39 years) with CF had dual energy X-ray absorptiometry and direct segmental multi-frequency impedance analysis. Body composition, pulmonary function, respiratory muscle function and exercise tolerance using the impedance device were measured in 29 young people with CF with median age 15 (range 12-19) years. MAIN FINDINGS: There was a significant correlation between impedance and absorptiometry results (r2 = 0.947). Fat free mass correlated with the forced vital capacity z-score (r = 0.442, p = 0.016), maximal inspiratory pressure (r = 0.451, p = 0.014) and exercise tolerance (r = 0. 707, p < 0.001). BMI z-scores did not significantly correlate with pulmonary or respiratory muscle function. Subjects with a fat free mass z-score of ≤2 had a lower forced expiratory volume in 1 s z-score (p = 0.007), lower forced vital capacity z-score (p = 0.001), higher residual volume z-score (p = 0.042), lower maximal inspiratory pressure (p = 0.039), more days of intravenous antibiotics per year (p = 0.016) and a higher rate of chronic infections (p = 0.006). PRINCIPAL CONCLUSIONS: Fat-free mass measured by impedance correlated better with pulmonary and respiratory muscle function and exercise capacity than BMI.
Authors: Dionne Adair; Ahmad Hider; Amy G Filbrun; Chris Tapley; Sandra Bouma; Courtney Iwanicki; Samya Z Nasr Journal: Front Pediatr Date: 2022-01-13 Impact factor: 3.418
Authors: Francisco José Sánchez-Torralvo; Nuria Porras; Ignacio Ruiz-García; Cristina Maldonado-Araque; María García-Olivares; María Victoria Girón; Montserrat Gonzalo-Marín; Casilda Olveira; Gabriel Olveira Journal: Nutrients Date: 2022-08-17 Impact factor: 6.706
Authors: Andrea Granados; Elizabeth A Beach; Andrew J Christiansen; Bruce W Patterson; Michael Wallendorf; Ana María Arbeláez Journal: J Cyst Fibros Date: 2021-06-26 Impact factor: 5.527
Authors: Kevin J Scully; Laura T Jay; Steven Freedman; Gregory S Sawicki; Ahmet Uluer; Joel S Finkelstein; Melissa S Putman Journal: Nutrients Date: 2022-01-12 Impact factor: 5.717