Literature DB >> 30170694

Docosahexaenoic acid induces changes in microglia/macrophage polarization after spinal cord injury in rats.

Olga Manzhulo1, Anna Tyrtyshnaia2, Yulia Kipryushina1, Inessa Dyuizen1, Igor Manzhulo3.   

Abstract

Docosahexaenoic acid (DHA, 22:6 (n-3)) leads to recovery of locomotor functions observed of spinal cord injury (SCI) in rats. In present study, we characterized the expression of iba-1, CD86, CD163 in microglia/macrophages, to assess activation state and M1 (pro-inflammatory)/M2 (anti-inflammatory) phenotypes respectively, in the rostral, central and caudal segment of the spinal cord on 7 and 35 days after SCI. We found that DHA treatment leads to: (1) an increased activation and proliferation of microglial cells; (2) an alteration in the dynamics between M1 and M2 microglia/macrophages phenotypes (3) and increased production of an antioxidant enzymes. Overall, our data demonstrates that DHA has a complex effect in post-traumatic process within the central nervous system, and supports the therapeutic potential of DHA-based drugs.
Copyright © 2018 Elsevier GmbH. All rights reserved.

Entities:  

Keywords:  CD163; CD86; DHA; SCI; SOD; iba-1

Mesh：

Substances：

Year:  2018        PMID： 30170694     DOI： 10.1016/j.acthis.2018.08.005

Source DB:  PubMed          Journal:  Acta Histochem        ISSN： 0065-1281            Impact factor:   2.479


  6 in total

1.  Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury.

Authors:  Qiao Zheng; Jiawei Zhang; Xiaoshuang Zuo; Jiakai Sun; Zhuowen Liang; Xueyu Hu; Zhe Wang; Kun Li; Jiwei Song; Tan Ding; Xuefeng Shen; Yangguang Ma; Penghui Li
Journal:  J Mol Neurosci       Date:  2021-01-08       Impact factor: 3.444

Review 2.  Roles of Fatty Acids in Microglial Polarization: Evidence from In Vitro and In Vivo Studies on Neurodegenerative Diseases.

Authors:  Miey Park; Hae-Jeung Lee
Journal:  Int J Mol Sci       Date:  2022-06-30       Impact factor: 6.208

3.  Spinal Cord Microglia in Health and Disease.

Authors:  E A Kolos; D E Korzhevskii
Journal:  Acta Naturae       Date:  2020 Jan-Mar       Impact factor: 1.845

4.  Effect of docosahexaenoic acid on the recovery of motor function in rats with spinal cord injury: a meta-analysis.

Authors:  Zi-Rui Tian; Min Yao; Long-Yun Zhou; Yong-Jia Song; Jie Ye; Yong-Jun Wang; Xue-Jun Cui
Journal:  Neural Regen Res       Date:  2020-03       Impact factor: 5.135

5.  The Conditioned Medium of Lactobacillus rhamnoides GG Regulates Microglia/Macrophage Polarization and Improves Functional Recovery after Spinal Cord Injury in Rats.

Authors:  Fangqi Lin; Baokun Zhang; Qiang Shi; Jiaming Liang; Xin Wang; Xiaofeng Lian; Jianguang Xu
Journal:  Biomed Res Int       Date:  2021-07-10       Impact factor: 3.411

6.  Fish Hydrolysate Supplementation Containing n-3 Long Chain Polyunsaturated Fatty Acids and Peptides Prevents LPS-Induced Neuroinflammation.

Authors:  Mathilde Chataigner; Marie Martin; Céline Lucas; Veronique Pallet; Sophie Layé; Alexis Mehaignerie; Elodie Bouvret; Anne-Laure Dinel; Corinne Joffre
Journal:  Nutrients       Date:  2021-03-02       Impact factor: 5.717
  6 in total

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