Mahdieh Molanouri Shamsi1, Soodabeh Chekachak2, Sara Soudi3, Reza Gharakhanlou2, LeBris S Quinn4, Kia Ranjbar2, Sajjad Rezaei2, Fatemeh Jalali Shirazi3, Begrouz Allahmoradi2, Mohammad H Yazdi5, Mehdi Mahdavi6, Fabricio Azevedo Voltarelli7. 1. Physical Education and Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. Electronic address: molanouri@modares.ac.ir. 2. Physical Education and Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. 3. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. 4. Research Service, VA Puget Sound Health Care System and Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA. 5. Department of Pharmaceutical Biotechnology and Biotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 6. Immunology Department, Pasteur Institute of Iran, Tehran, Iran; Recombinant vaccine research center, Tehran University of Medical Sciences, Tehran, Iran. 7. Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil.
Abstract
OBJECTIVES: Physical exercise decreases the incidence of breast cancer and also improves survival in breast cancer patients. However, the mechanistic basis of these protective effects of exercise is not well known. Changes in tumor cytokines, such as oncostatin-M (OSM), have been associated with modulation of antitumor immune responses in breast cancer. Exercise and antioxidants such as selenium affect both antitumor immune responses as well as tumor cytokine expression. Thus, the aim of this study was to determine the effects of aerobic exercise training (AET) and selenium nanoparticle (SeNP) administration on T-helper 1 and 2 and tumor tissue cytokines in mice bearing the 4 T1 mammary carcinoma. METHODS: We examined the effects of 6 wk of AET and SeNP administration (100 μg three times/wk) on tumor size, concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-4 and OSM in tumor tissue and INF-γ and IL-4 in splenocytes of 64 mice bearing the 4 T1 mammary carcinoma. RESULTS: AET increased OSM levels in tumor tissue. Moreover, AET increased levels of TNF-α in tumor tissue, whereas SeNP supplementation decreased IL-4 levels tumor tissue. Also, the combination of AET and SeNP administration decreased tumor volume and increased T-helper 1 cytokines in the splenocytes of tumor-bearing mice. CONCLUSION: These findings suggest that the combination of AET and SeNP supplementation effects antitumor immune responses in splenocytes, whereas AET induced antitumor cytokines, such as OSM and TNF-α in tumor tissue.
OBJECTIVES: Physical exercise decreases the incidence of breast cancer and also improves survival in breast cancerpatients. However, the mechanistic basis of these protective effects of exercise is not well known. Changes in tumor cytokines, such as oncostatin-M (OSM), have been associated with modulation of antitumor immune responses in breast cancer. Exercise and antioxidants such as selenium affect both antitumor immune responses as well as tumor cytokine expression. Thus, the aim of this study was to determine the effects of aerobic exercise training (AET) and selenium nanoparticle (SeNP) administration on T-helper 1 and 2 and tumor tissue cytokines in mice bearing the 4 T1 mammary carcinoma. METHODS: We examined the effects of 6 wk of AET and SeNP administration (100 μg three times/wk) on tumor size, concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-4 and OSM in tumor tissue and INF-γ and IL-4 in splenocytes of 64 mice bearing the 4 T1 mammary carcinoma. RESULTS:AET increased OSM levels in tumor tissue. Moreover, AET increased levels of TNF-α in tumor tissue, whereas SeNP supplementation decreased IL-4 levels tumor tissue. Also, the combination of AET and SeNP administration decreased tumor volume and increased T-helper 1 cytokines in the splenocytes of tumor-bearing mice. CONCLUSION: These findings suggest that the combination of AET and SeNP supplementation effects antitumor immune responses in splenocytes, whereas AET induced antitumor cytokines, such as OSM and TNF-α in tumor tissue.
Authors: Carmen Griñan-Lison; Jose L Blaya-Cánovas; Araceli López-Tejada; Marta Ávalos-Moreno; Alba Navarro-Ocón; Francisca E Cara; Adrián González-González; Jose A Lorente; Juan A Marchal; Sergio Granados-Principal Journal: Antioxidants (Basel) Date: 2021-01-31